تاثیر مصرف عصاره ماریتیغال (Silybum marianum) در خلال تمرینات هوازی بر برخی شاخص های اندوتلیال عروقی در زنان سندرم متابولیک

محورهای موضوعی : فصلنامه زیست شناسی جانوری

الهام صادقی فر ¹ , عبدالعلی بنائی فر ² , وحید ایمانی پور ³ , سجاد ارشدی ⁴

1 - گروه تربیت بدنی و علوم ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران
2 - گروه تربیت بدنی و علوم ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران
3 - گروه تربیت بدنی و علوم ورزشی، واحد پرند، دانشگاه آزاد اسلامی، پرند، ایران
4 - گروه تربیت بدنی و علوم ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران

تاریخ دریافت : 1403/01/27 تاریخ پذیرش : 1403/04/09 تاریخ انتشار : 1403/10/23

کلید واژه: نیتریک اکساید, ذرات کوچک اندوتلیال, ورزش هوازی, عصاره خارمريم, سندرم متابولیک,

چکیده مقاله :

چاقی و بیماری‌های وابسته با ناهنجاری­های قلبی-عروقی همراهند. این مطالعه با هدف تعیین اثر تمرینات هوازی و عصاره خارمريم بر سطوح سرمی نیتریک اکساید (NO) و ذرات کوچک اندوتلیال (EMPs) در زنان چاق دارای سندرم متابولیک انجام گرفت. در این مطالعه نیمه تجربی، 48 زن چاق دارای سندرم متابولیک در دامنه سنی 40-30 سال به شیوه تصادفی به گروه‌های کنترل (بدون مداخله)؛ عصاره خارمريم (روزانه 1000 گرم)؛ ورزش (تمرین هوازی/یک روز در میان) و گروه ترکیبی (تمرین هوازی + عصاره خار مريم) تقسیم شدند. اجرای تمرینات هوازی و مصرف خارمريم، 8 هفته به طول انجامید. سطوح ناشتایی NO  وEMPs  و شاخص های آنتروپومتریکی در شرایط قبل و بعد از مداخله در همه گروه‌ها اندازه­گیری شد. برای مقایسه داده‌ها از آزمون آماری آنکوا استفاده شد (05/0 > p). در مقایسه با گروه کنترل، نیتریک اکساید سرم در گروه ورزش و ترکیبی به میزان معنی‌داری افزایش پیدا کرد (001/0<  p). در گروه ترکیبی،NO  وEMPs  سرم به میزان معنی‌داری نسبت به سایر گروه‌ها به ترتیب افزایش و کاهش یافتند. مصرف عصاره خارمريم در طول تمرینات هوازی با اثرات قلبی-عروقی و اندوتلیالی بیشتری نسبت به اعمال هر یک از آنها به تنهایی همراه است. شناخت مکانیسم­های اصلی این تغییرات مستلزم مطالعات بیشتر در این زمینه است.

چکیده انگلیسی:

Obesity and related diseases are associated with cardiovascular. In this study, we aimed to assess the effect of aerobic exercise and milk Thistle extract on serum nitric oxide (NO) and endothelial microparticles (EMPs) in obese women with metabolic syndrome. In this quasi-experimental research, 48 obese women with metabolic syndrome, aged 35-40 years, were randomly divided into control (no intervention); milk thistle extract (280 mg /daily); exercise (aerobic exercise /every other day) and combined group (aerobic exercise + Milk thistle). Aerobic exercise and milk Thistle intake lasted for 8 weeks. Fasting NO and EMPs levels and anthropometric indices were measured before and after the intervention in all groups. Data were compared by ANCOVA between groups (p < 0.05). Compared to control group, serum NO significantly increased in the exercise and combined groups (p < 0.001). In combined group, serum NO and EMPs were significantly increased and decreased respectively in compared to other groups. The consumption of milk thistle extract during aerobic exercise is associated with more cardiovascular and endothelial effects than the application of each of them alone. Understanding the underlying mechanisms of these changes requires further studies in this field.

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