Flaxseed oil Ameliorated the expression level of the IL-1β/NLRP3/NRF-1/Sirt-1of diabetic heart conditions.

محورهای موضوعی : Exercise Physiology and Performance

Farzad Forootan ¹ (Molecular Pathology Laboratory, Department of Molecular and Clinical Cancer Medicine, Liverpool University, Liverpool L69 3GA, United Kingdom)
Fatemeh Zahra Abdollahi ² (Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.)
Mitra Shafie ³ (Department of Plant Biotechnology, Medicinal Plants Research Centre, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.)

تاریخ دریافت : 1403/02/09 تاریخ پذیرش : 1403/02/15 تاریخ انتشار : 1403/03/28

کلید واژه: cardiovascular diseases, Flaxseed, H9c2, genes,

چکیده مقاله :

Background: Inflammation and cytokine storms due to cardiovascular diseases (CD). Herbals can be the primary source of compounds with anti-inflammatory properties. Furthermore, herbals agents may consider as a complementary medicine. Bioactive compounds and phytochemicals have potential strategies to halt or manage CD. flaxseed have antioxidant and anti-inflammatory activity. Methods: In this study, we used H9c2 cell lines of rat embryonic cardiomyocytes. To induce CD we used hyperglycemic and hyperlipidemic conditions. Real-Time-PCR performed to evaluated the relative expression of the genes. Results: We found that flaxseed could decreased the expression level of the IL-1β and NLRP3. Moreover, the expression level of the NRF-1 and Sirt-1 increased by flaxseed. Conclusion: Our data proposed that flaxseed could have potential approaches to manage and prevent CD.

چکیده انگلیسی:

Background: Inflammation and cytokine storms due to cardiovascular diseases (CD). Herbals can be the primary source of compounds with anti-inflammatory properties. Furthermore, herbals agents may consider as a complementary medicine. Bioactive compounds and phytochemicals have potential strategies to halt or manage CD. flaxseed have antioxidant and anti-inflammatory activity. Methods: In this study, we used H9c2 cell lines of rat embryonic cardiomyocytes. To induce CD we used hyperglycemic and hyperlipidemic conditions. Real-Time-PCR performed to evaluated the relative expression of the genes. Results: We found that flaxseed could decreased the expression level of the IL-1β and NLRP3. Moreover, the expression level of the NRF-1 and Sirt-1 increased by flaxseed. Conclusion: Our data proposed that flaxseed could have potential approaches to manage and prevent CD.

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