Characterization and Investigation of Bredigite Nanostructure (BRN) Bioactivity as a Bio ceramic Using Bone Tissue Engineering
محورهای موضوعی : Journal of NanoanalysisEbrahim Karamian 1 , Aimr Hossein Shalbaf 2
1 - IAUN
2 - department of materials,najafabad university
کلید واژه: Bredigite , Nanostructure materials , Bioactivity, Hydroxyapatite, Bioceramics ,
چکیده مقاله :
Bredigite Nanostructure (BRN) is a calcium silicate mineral with composition Ca7MgSi4O16. Lately, Bredigite Nanostructure (BRN) has been introduced as a bioceramic materials due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HA). In this project, bioactivity of Bredigite Nanostructure (BRN) powder were evaluated and investigated. For synthesis of BRN powder, Magnesium nitrate hexahydrate (Mg (NO3)2.6H2O), Calcium nitrate tetra hydrate (Ca (NO₃)₂ .4H₂O) powders and Tetraethyl ortho silicate liquid (TEOS) was used and using Sol-Gel process. In this part, for survey of bioactivity evaluation, the BRN synthesized powders were pressed and sintered then immersed in Kukobo solution (SBF) for 28 days at 37 °C in incubator. The results indicated that nano-struacture bredigite powder with crystalline size is 45 nm. The apatite formation ability, bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical engineering.
Bredigite Nanostructure (BRN) is a calcium silicate mineral with composition Ca7MgSi4O16. Lately, Bredigite Nanostructure (BRN) has been introduced as a bioceramic materials due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HA). In this project, bioactivity of Bredigite Nanostructure (BRN) powder were evaluated and investigated. For synthesis of BRN powder, Magnesium nitrate hexahydrate (Mg (NO3)2.6H2O), Calcium nitrate tetra hydrate (Ca (NO₃)₂ .4H₂O) powders and Tetraethyl ortho silicate liquid (TEOS) was used and using Sol-Gel process. In this part, for survey of bioactivity evaluation, the BRN synthesized powders were pressed and sintered then immersed in Kukobo solution (SBF) for 28 days at 37 °C in incubator. The results indicated that nano-struacture bredigite powder with crystalline size is 45 nm. The apatite formation ability, bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical engineering.
1.H.Gheisari , E.Karamian and M.Abdellahi , A novel hydroxyapatite –Hardystonite nanocompositeceramic , Ceramics International.2015; 4 (2): 5967–5975.
2. H.Gheisari and E.Karamian , Preparation and characterization of hydroxyapatite reinforced with hardystonite as a novel bio-nanocomposite for tissue engineering ,2014; 1(2): 298- 301.
3.Thakkar KN, Mhatre SS, Parikh RY. Biological synthesis of metallic nanoparticles. Nanomed J. 2010; 6(2): 257–262.
4- D. Yi, C. Wu, B. Ma, H. Ji, X. Zheng, J. Chang, Bioactive bredigite coating with improved bonding strength, rapid apatite mineralization and excellent cytocompatibility, Journal of biomaterials applications (2014) 28(9),1343-1353.
5- C. Wu, J. Chang, Synthesis and in vitro bioactivity of bredigite powders, Journal of biomaterials applications 21(3) (2007) 251-263.
6- W. Zhai, H. Lu, C. Wu, L. Chen, X. Lin, K. Naoki, G. Chen, J. Chang, Stimulatory effects of the ionic products from Ca–Mg–Si bioceramics on both osteogenesis and angiogenesis in vitro, Acta biomaterialia 9(8) (2013) 8004-8014.
7- X. Bao, M. He, Z. Zhang, X. Liu, Crystal structure and some thermodynamic properties of Ca7MgSi4O16-bredigite, Crystals 11(1) (2020) 14.
8- Z. Huang, S. Yu, Microstructure characterization on the formation of in situ Mg2Si and MgO reinforcements in AZ91D/Flyash composites, Journal of Alloys and Compounds 509(2) (2011) 311-315.
9- S.N. Dezfuli, Z. Huan, A. Mol, S. Leeflang, J. Chang, J. Zhou, Advanced bredigite-containing magnesium-matrix composites for biodegradable bone implant applications, Materials Science and Engineering: C 79 (2017) 647-660.
10-M. Kouhi, M. Shamanian, M. Fathi, A. Samadikuchaksaraei, A. Mehdipour, Synthesis, characterization, in vitro bioactivity and biocompatibility evaluation of hydroxyapatite/bredigite (Ca7 MgSi4O16) composite nanoparticles, Jom 68(4) (2016) 1061-1070.
11- Kim, H. M.; Miyazaki, T.; Kokubo, T.; Nakamura, T. Key Eng. Mater. 2001, 192–195, 47–50.
12-Ahmad Monshi, Mohammad Reza Foroughi, Mohammad Reza Monshi , Modified Scherrer Equation to Estimate More Accurately Nano-Crystallite Size Using XRD, World Journal of Nano Science and Engineering, Vol.2 No.3, September 2012.
