سنتز ذرات کلسیم فسفاتی به روش احتراق در محلول و بررسی تغییر pH اولیه و دمای عملیات حرارتی بر خواص فیزیکی و زیستی پودر حاصل
محورهای موضوعی : فصلنامه علمی - پژوهشی مواد نوین
ندا سامی
1
,
سحر ملازاده بیدختی
2
,
جلیل وحدتی خاکی
3
1 - دانشجوی کارشناسی‌ارشد رشته مهندسی مواد، گروه مهندسی مواد، دانشگاه فردوسی مشهد، مشهد، ایران
2 - استادیار، گروه مهندسی مواد، گروه مهندسی مواد، دانشگاه فردوسی مشهد، مشهد، ایران
3 - استاد، گروه مهندسی مواد، دانشگاه فردوسی مشهد، مشهد، ایران
کلید واژه: کلسیم فسفات, فلور آپاتیت, هیدروکسی آپاتیت, pH محلول, دمای عملیات حرارتی,
چکیده مقاله :
مقدمه: هیدروکسی آپاتیت یک ماده معدنی طبیعی است که در اجزای استخوان یافت می‌شود. گروه هیدروکسیل آن می‌تواند با یون‌های فلوراید جایگزین شده و طیف وسیعی از آپاتیت‌ها را ایجاد نماید. فلوئور آپاتیت یکی از موادی است که می‌تواند یون F- را با نرخ کنترل شده آزاد نماید. جایگزینی یون فلوراید موجب بهبود تکثیر سلولی و فعال‌سازی سلول‌های استخوان‌ساز به سطح ایمپلنت می‌شود.
روش: در این پژوهش ذرات کلسیم فسفات به روش سنتز احتراقی در محلول‌هایی با مقادیر متفاوت عامل قلیایی و در دمای محیط سنتز شدند. ذرات سنتز شده در pHهای متفاوت پس از شستشو و سانتریفیوژ، در محیط خلأ با دمای ℃۹۰ خشک شدند. پس از تهیه پودرها، در محدوده دمایی ℃۸۵۰ تا ℃11۰۰ عملیات حرارتی انجام گرفت. خواص فیزیکی و زیستی نمونه‌های تهیه شده در pH و دماهای متفاوت مورد بررسی قرار گرفت.
یافته ها: نتایج به‌دست‌آمده نشان داد که افزایش pH محلول و دمای عملیات حرارتی، منجر به افزایش رهایش یون فلوئور می‌گردد. همچنین مشخص شد که افزایش pH در محلول اولیه سنتز، باعث کاهش اندازه ذرات از حدود nm500 در pH=10 به مقادیر 100nm در pH=10 شد. این موضوع ناشی از بهبود یکنواختی در محلول اولیه سنتز است.
نتیجه گیری: می‌توان این‌گونه برداشت کرد که محصول این پژوهش می‌تواند جایگزینی برای بافت آسیب‌دیده استخوان باشد. زیرا که هم‌زمان دوفاز هیدروکسی آپاتیت و فلوئور آپاتیت را در خود دارد که منجر به کنترل رهایش و جذب یون‌های معدنی خواهد شد.
Introduction: Hydroxyapatite is a natural mineral found in bone components. Fluoride ions can replace its hydroxyl group to form a wide range of apatites. Fluoroapatite is one of the materials that can release F- ions at a controlled rate. Fluoride ion replacement improves cell proliferation and activation of osteogenic cells to the implant surface.
Methods: In this study, calcium phosphate particles were synthesized by combustion synthesis in solutions with different amounts of alkaline agent and at ambient temperature. The synthesized particles were dried to varying pHs after washing and centrifugation in a vacuum environment and at 90℃. After preparing powders, all samples were heat treated at a temperature range of 850 to 1100°C. The physical and biological properties of the samples prepared at different pHs and temperatures were investigated.
Findings: The results showed that increasing the solution's pH and heat treat temperature increased the release of fluoride ions. It was also found that increasing the pH in the initial synthesis solution decreased the particle size from about 500 nm at pH=8 to 100 nm at pH=10. This is due to the improvement in the uniformity of the initial synthesis solution. The result of this research can be a substitute for damaged bone tissue. Because it simultaneously contains two phases of hydroxyapatite and fluorapatite, which will lead to the control of the release and absorption of mineral ions.
Conclusion: In conclusion, hydroxyfluoroapatite particles produced through combustion synthesis in solution exhibit promising characteristics for bone tissue repair. The synthesized samples retain their fluoroapatite phase after contact with simulated body fluid for three weeks, demonstrating chemical stability. Furthermore, the presence of hydroxyapatite enhances the release of fluorine ions, indicating potential suitability for bioremediation. Therefore, the combination of hydroxyapatite and fluoroapatite phases offers a viable option for effective bone tissue regeneration.
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