Effects of Aerobic Training and Crocin on Metabolic-Related Body Weight Alterations Following Methamphetamine Exposure in Female Rats
محورهای موضوعی : NutritionMostafa Mozaffari 1 , Somaye Rajabi 2 , Sayyed- Javad Ziaolhagh 3 , Nematollah Nemati 4
1 - Department of Exercise Physiology, Da.C., Islamic Azad University, Damghan, Iran
2 - Department of Exercise Physiology,Sh.C., Islamic Azad University, Shahroud, Iran
3 - Department of Exercise Physiology,Sh.C., Islamic Azad University, Shahroud, Iran
4 - Ziaolhagh
کلید واژه: Aerobic Training, Metabolic-related body weight alterations, Methamphetamine, Saffron,
چکیده مقاله :
Methamphetamine (METH) disrupts metabolism and body weight. Aerobic exercise and saffron stigma extract, with antioxidant and anti-inflammatory properties, may counteract these effects. This study explores their combined impact on METH-induced metabolic disturbances in female Wistar rats. Thirty female Wistar rats were randomly divided into five groups (n=6): (1) control, (2) METH-treated, (3) METH + aerobic exercise, (4) METH + saffron, and (5) METH + aerobic exercise + saffron. Methamphetamine was administered intraperitoneally at 10 mg/kg/day. Aerobic training consisted of treadmill running (25 m/min, 30 minutes/day, 6 days/week) for 4 weeks. Saffron extract (40 mg/kg) was also administered intraperitoneally. Body weight measured every week for Metabolic-Related Body Weight Alterations. METH significantly increased body weight compared to controls (p < 0.0001). Both aerobic exercise and crocin attenuated METH-induced weight gain, with the combined intervention showing the most pronounced effect (p < 0.0001 vs. METH). Two-way ANOVA revealed significant main effects of time (F(1,25) = 812.4, p < 0.0001), group (F(4,25) = 64.7, p < 0.0001), and a time × group interaction (F(4,25) = 31.9, p < 0.0001). Aerobic exercise and crocin, particularly when combined, effectively mitigate METH-induced alterations in body weight, likely via modulation of oxidative stress, inflammatory responses, and energy-regulating neuroendocrine pathways. These findings suggest potential therapeutic strategies for managing the metabolic consequences of methamphetamine exposure.
Methamphetamine (METH) disrupts metabolism and body weight. Aerobic exercise and saffron stigma extract, with antioxidant and anti-inflammatory properties, may counteract these effects. This study explores their combined impact on METH-induced metabolic disturbances in female Wistar rats. Thirty female Wistar rats were randomly divided into five groups (n=6): (1) control, (2) METH-treated, (3) METH + aerobic exercise, (4) METH + saffron, and (5) METH + aerobic exercise + saffron. Methamphetamine was administered intraperitoneally at 10 mg/kg/day. Aerobic training consisted of treadmill running (25 m/min, 30 minutes/day, 6 days/week) for 4 weeks. Saffron extract (40 mg/kg) was also administered intraperitoneally. Body weight measured every week for Metabolic-Related Body Weight Alterations. METH significantly increased body weight compared to controls (p < 0.0001). Both aerobic exercise and crocin attenuated METH-induced weight gain, with the combined intervention showing the most pronounced effect (p < 0.0001 vs. METH). Two-way ANOVA revealed significant main effects of time (F(1,25) = 812.4, p < 0.0001), group (F(4,25) = 64.7, p < 0.0001), and a time × group interaction (F(4,25) = 31.9, p < 0.0001). Aerobic exercise and crocin, particularly when combined, effectively mitigate METH-induced alterations in body weight, likely via modulation of oxidative stress, inflammatory responses, and energy-regulating neuroendocrine pathways. These findings suggest potential therapeutic strategies for managing the metabolic consequences of methamphetamine exposure.
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