• صفحه اصلی
  • The effect of aerobic and resistance exercise with olive extract on VO2 max, PTEN, and AKT in rats with Parkinson's disease

اشتراک گذاری

آدرس مقاله


کد مقاله : JPAH-2309-1088 (R1) بازدید : 267 صفحه: 25 - 35

نوع مقاله: پژوهشی

The effect of aerobic and resistance exercise with olive extract on VO2 max, PTEN, and AKT in rats with Parkinson's disease

محورهای موضوعی : Journal of Physical Activity and Hormones

Seyedeh Soheila Bolhagh 1 , Ramin Shabani 2 , Donya Sajedi 3

1 - Ph.D. Candidate in Exercise Physiology, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran
2 - Professor, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran
3 - Ph.D. in Exercise Physiology, Young Researchers and Elite Club, Rasht Branch, Islamic Azad University, Rasht, Iran

تاریخ دریافت : 1402/06/17 تاریخ پذیرش : 1402/07/11 تاریخ انتشار : 1402/06/10

کلید واژه: Exercise, AKT, Olive extract, PTEN, Parkinson disease,

چکیده مقاله :

Introduction: Parkinson's disease is a progressive neurological disorder. The aim of this study was to investigate the effect of exercise training with the consumption of olive extract on maximal oxygen consumption (VO2 max), phosphatase and tensin homolog on chromosome 10 (PTEN), and protein kinase B (AKT) in rats with Parkinson.Material & Methods:The samples of this experimental study included male Wistar rats (n = 30, 8 weeks old, 200 ± 50 g). Animals were randomly divided into six groups: control (C), Parkinson's (P), Parkinson's with olive extract (P+OE), Parkinson's with exercise (P+E), Parkinson's with olive extract and exercise (P+OE+E), and olive extract with exercise (OE+E) group (n = 5 per group). The training groups performed aerobic and resistance exercises for eight weeks (5 sessions per week) and were given olive extract by gavage. VO2 max was assessed at the end of the fourth and eighth weeks of exercise. One day after the intervention, rats were sacrificed, and tissues were removed and examined for real-time PCR. One-way analysis of variance and Tukey's post hoc test were used to analyze the data.Results:The results showed that a period of exercise training combined with the consumption of olive extract significantly increased the VO2 max in rats with Parkinson's disease (P < 0.05). The expression of the PTEN gene decreased in OE+E, P+OE+E, and P+E groups compared to P+OE and Parkinson's groups (P<0.05). AKT gene expression in all intervention groups significantly increased compared to the Parkinson's group (P<0.05).Conclusions:The results suggest that a period of exercise with the consumption of olive extract probably can increase the VO2 max and AKT and decrease PTEN in rats with Parkinson's disease.

چکیده انگلیسی:

منابع و مأخذ:

References

 

  1. Azizi S, Kargarfard M, Azizi R. Effects of 8 weeks of water-based exercise on the lower limb muscles strength in Parkinson's. Koomesh journal. 2014;16(1):60-6. eng.
    2.
  2. Durmus B, Baysal O, Altinayar S, Altay Z, Ersoy Y, Ozcan C. Lower extremity isokinetic muscle strength in patients with Parkinson’s disease. Journal of Clinical Neuroscience. 2010;17(7):893-6.
    3.
  3. Haas-Kogan D, Stokoe D. PTEN in brain tumors. Expert review of neurotherapeutics. 2008;8(4):599-610.
    4.
  4. Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, et al. PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences. 2001;98(8):4622-7.
    5.
  5. Gary DS, Mattson MP. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. 2002;2(3):261-9.
    6.
  6. Salinas M, Martı́n D, Alvarez A, Cuadrado A. Akt1/PKBα protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Molecular and Cellular Neuroscience. 2001;17(1):67-77.
    7.
  7. Fan G-C, Zhou X, Wang X, Song G, Qian J, Nicolaou P, et al. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation research. 2008;103(11):1270-9.
    8.
  8. Dávila D, Fernández S, Torres-Alemán I. Astrocyte resilience to oxidative stress induced by insulin-like growth factor I (IGF-I) involves preserved AKT (protein kinase B) activity. Journal of Biological Chemistry. 2016;291(5):2510-23.
    9.
  9. Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, et al. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. 2012.
    10.
  10. Devireddy S, Liu A, Lampe T, Hollenbeck PJ. The organization of mitochondrial quality control and life cycle in the nervous system vivo in the absence of PINK1. Journal of Neuroscience. 2015;35(25):9391-401.
    11.
  11. Li L, Hu G-k. Pink1 protects cortical neurons from thapsigargin-induced oxidative stress and neuronal apoptosis. Bioscience Reports. 2015;35(1).
    12.
  12. Oliveras-Salvá M, Macchi F, Coessens V, Deleersnijder A, Gérard M, Van der Perren A, et al. Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice. Neurobiology of aging. 2014;35(11):2625-36.
    13.
  13. Burbulla LF, Fitzgerald J, Stegen K, Westermeier J, Thost A, Kato H, et al. Mitochondrial proteolytic stress induced by loss of mortal in function is rescued by Parkin and PINK1. Cell death & disease. 2014;5(4):e1180-e.
    14.
  14. Dai H, Deng Y, Zhang J, Han H, Zhao M, Li Y, et al. PINK1/Parkin-mediated mitophagy alleviates chlorpyrifos-induced apoptosis in SH-SY5Y cells. Toxicology. 2015;334:72-80.
    15.
  15. Büeler H. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Experimental neurology. 2009;218(2):235-46.
    16.
  16. Kwak H-J, Liu P, Bajrami B, Xu Y, Park S-Y, Nombela-Arrieta C, et al. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015;42(1):159-71.
    17.
  17. Gupta SC, Singh R, Pochampally R, Watabe K, Mo Y-Y. Acidosis promotes the invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway. Oncotarget. 2014;5(23):12070.
    18.
  18. Seo JH, Ahn Y, Lee S-R, Yeo CY, Hur KC. The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. Molecular biology of the cell. 2005;16(1):348-57.
    19.
  19. Castorena CM, Arias EB, Sharma N, Cartee GD. Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats. Diabetes. 2014;63(7):2297-308.
    20.
  20. Elmarakby AA, Sullivan JC. Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. Cardiovascular therapeutics. 2012;30(1):49-59.
    21.
  21. Yasuhara T, Hara K, Maki M, Matsukawa N, Fujino H, Date I, et al. Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis. Neuroscience. 2007;149(1):182-91.
    22.
  22. O’dell S, Gross N, Fricks A, Casiano B, Nguyen T, Marshall J. Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience. 2007;144(3):1141-51.
    23.
  23. Battistelli M, Malatesta M, Meschini S. Oxidative stress to promote cell death or survival. Hindawi; 2016.
    24.
  24. Alaei H, Moloudi R, Sarkaki AR. Effects of treadmill running on mid-term memory and swim speed in the rat with Morris water maze test. Journal of Bodywork and Movement Therapies. 2008;12(1):72-5.
    25.
  25. Souza MVC, Leite RD, de Souza Lino AD, de Cássia Marqueti R, Bernardes CF, de Araújo HSS, et al. Resistance training improves body composition and increases matrix metalloproteinase 2 activity in biceps and gastrocnemius muscles of diet-induced obese rats. Clinics. 2014;69:265-70.
    26.
  26. De Souza E, Tricoli V, Bueno Junior C, Pereira M, Brum P, Oliveira E, et al. The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70 S6K1 and AMPK signaling pathway responses in rat skeletal muscle. Brazilian Journal of Medical and Biological Research. 2013;46:343-7.
    27.
  27. Mattson MP. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain research. 2000;886(1-2):47-53.
    28.
  28. Dashtiyan AA, Afzalpour ME, Tanideh N, Sepehrimanesh M. The comparison of the effect of vitamin E on the expression of p53/PTEN of prostate gland of male rats in two groups of intensive continuous and intermittent exercise training. Journal of Advanced Biomedical Sciences. 2017;7(3):406-15. Fa.
    29.
  29. Radak Z, Chung HY, Goto S. Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology. 2005;6(1):71-5.
    30.
  30. Friedrich M. Parkinson disease studies yield insights. Jama. 2005;293(4):409-10.
    31.
  31. Bloomer RJ, Schilling BK, Karlage RE, Ledoux MS, Pfeiffer RF, Callegari J. Effect of resistance training on blood oxidative stress in Parkinson disease. Medicine and science in sports and exercise. 2008;40(8):1385-9.
    32.
  32. Tuon T, Valvassori S, Lopes-Borges J, Luciano T, Trom C, Silva L, et al. Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson’s disease. Neuroscience. 2012;227:305-12.
    33.
  33. Fallah-Mohammadi Z, Aghasi M, Ahmadi-Kordasiai M. Neuroprotective effects of exercise with hydroalcoholic extraction of Eriobotrya japonica on MANF in the Brainstem of parkinson's rats. Journal of Shahrekord University of Medical Sciences. 2014;16(3).
    34.
  34. Aytul KK. Antimicrobial and antioxidant activities of olive leafextract and its food applications: Izmir Institute of Technology (Turkey); 2010.
    35.
  35. Sarbishegi M, Mehraein F, Soleimani M. Antioxidant role of oleuropein on midbrain and dopaminergic neurons of substantia nigra in aged rats. Iranian biomedical journal. 2014;18(1):16.
    36.
  36. Dekanski D, Selaković V, Piperski V, Radulović Ž, Korenić A, Radenović L. Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine. 2011;18(13):1137-43.
    37.
  37. Vauzour D, Rodriguez-Mateos A, Corona G, Oruna-Concha MJ, Spencer JP. Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients. 2010;2(11):1106-31.
    38.
  38. Hosseini F, Hosseini SA, Ahmadi M. The effect of a period of swimming training and chamomile extract on antioxidant status in adult male rats. Qom University of Medical Sciences Journal. 2018;12(6).
    39.
  39. Songstad NT, Kaspersen K-HF, Hafstad AD, Basnet P, Ytrehus K, Acharya G. Effects of high intensity interval training on pregnant rats, and the placenta, heart and liver of their fetuses. PloS one. 2015;10(11):e0143095.
    40.
  40. Acikgoz O, Aksu I, Topcu A, Kayatekin BM. Acute exhaustive exercise does not alter lipid peroxidation levels and antioxidant enzyme activities in rat hippocampus, prefrontal cortex and striatum. Neuroscience letters. 2006;406(1-2):148-51.
    41.
  41. Escribano B, Tunez I, Requena F, Rubio M, De Miguel R, Montilla P, et al. Effects of an aerobic training program on oxidative stress biomarkers in bulls. Veterinarni Medicina. 2010;55(9):422-8.
    42.
  42. Aksoy Y, Yapanoğlu T, Aksoy H, Demircan B, Öztaşan N, Canakci E, et al. Effects of endurance training on antioxidant defense mechanisms and lipid peroxidation in testis of rats. Archives of andrology. 2006;52(4):319-23.
    43.

سکوی نشر دانش

سند یا سکوی نشر دانش ،سامانه ای جهت مدیریت حوزه علمی و پژوهشی نشریات دانشگاه آزاد می باشد

پیوندهای سایت

مراکز مرتبط

پشتیبانی

صفحات رسمی

حقوق این وب‌سایت متعلق به سامانه مدیریت نشریات دانشگاه آزاد اسلامی است.
حق نشر © 1403-1400

صفحه اصلی| عضویت/ ورود| درباره سند| تماس با ما|
[English] [العربية] [en] [ar]