• صفحه اصلی
  • The Effects of Resistance Training With the Consumption of Saffron Extract on Spatial Memory and Tau Accumulation in the Hippocampal Tissue of Male Alzheimer's Induced Rats

اشتراک گذاری

آدرس مقاله


کد مقاله : JPAH-2309-1093 (R1) بازدید : 220 صفحه: 36 - 47

نوع مقاله: پژوهشی

The Effects of Resistance Training With the Consumption of Saffron Extract on Spatial Memory and Tau Accumulation in the Hippocampal Tissue of Male Alzheimer's Induced Rats

محورهای موضوعی : Journal of Physical Activity and Hormones

Fazel Bazyar 1 , Alireza Elmieh 2 , Tahereh Paravane Aval 3

1 - Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran
2 - Associate Professor, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran
3 - General Department of Education, Giluan Province, Iran

تاریخ دریافت : 1402/07/02 تاریخ پذیرش : 1402/07/09 تاریخ انتشار : 1402/06/10

کلید واژه: Resistance Exercises, spatial memory, saffron, Tao protein, Alzheimer's,

چکیده مقاله :

Introduction: Alzheimer's disease is a progressive, degenerative brain disease that causes severe thinking and memory impairment, and there is no definitive treatment for this disease. The present study aimed to investigate the effect of resistance training along with the consumption of saffron extract on spatial memory and tau accumulation in the hippocampal tissue of Alzheimer's male rats.Material & Methods: In this experimental study, 40 adult male rats were randomly divided into 4 Alzheimer's groups, including control, resistance exercise, resistance exercise, and supplement. Alzheimer's was induced by injecting amyloid beta 42-1 into the hippocampus. Resistance exercises were performed for 12 weeks, including three sessions per week. Y Maze test was used to measure spatial memory, and Tau protein was measured by the ELISA method. One-way analysis of variance tests was used to analyze the data.Results:The results showed that after 12 weeks of resistance training with saffron supplement, there was a significant increase in spatial memory performance in the intervention groups compared to the control group (P < 0.5). Also, regarding the amount of tau protein accumulation in the aerobic exercise group, aerobic exercise, and extract showed a significant decrease compared to the control group (P < 0.5).Conclusion: It seems that resistance exercise and consumption of saffron extract improve spatial memory performance and reduce the accumulation of tau protein in the hippocampal tissue of Alzheimer's male rats.

چکیده انگلیسی:

منابع و مأخذ:

References

 

  1. Ittner, L.M. and J. Götz, Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci, 2011. 12(2): p. 65-72.
    2.
  2. Fathi, F., et al., Effects of Sesame Oil on Improving Spatial Memory in Alzheimer's Disease. Journal of Babol University Of Medical Sciences, 2014. 16(2): p. 34-41.
    3.
  3. Parsa, N., Alzheimer’s disease: A medical challenge of 21st century. Journal of Arak University of Medical Sciences, 2011. 14(2): p. 100-108.
    4.
  4. Peri, A., and Serio, M. Neuroprotective effects of the Alzheimer’s disease-related gene Saladin-1. J Mol Endocrinol, 2008. 41(5): p. 251-61.
    5.
  5. Aghil, S., et al., Effect of aerobic exercise on some factors of cardiac apoptosis in male rats. Journal of Kashan University of Medical Sciences, 2019. 23(5): p. 495-502.
    6.
  6. Green, K.N. et al., Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-β and tau pathology via a mechanism involving presenilin one level. Journal of Neuroscience, 2007. 27(16): p. 4385-4395.
    7.
  7. Tepper, K. et al., Oligomer formation of tau protein hyperphosphorylated in cells. Journal of Biological Chemistry, 2014. 289(49): p. 34389-34407.
    8.
  8. Gharari.A., et al., The role of aerobic exercise and omega-3 supplementation on the level of phosphorylated tau protein in the hippocampus of Alzheimer's rats treated with homocysteine. Sport physiology, 2016. 8(31): p. 171-188.
    9.
  9. Khadijeh, E., et al., The effect of strength training on memory and spatial learning in Alzheimer's rats treated with beta-amyloid. medical scholar, 2016. 24(3): p. 9-18.
    10.
  10. Lukiw, W.J., Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD). Expert opinion on emerging drugs, 2012. 17(1): p. 43-60.
    11.
  11. Karceski, S., Preventing Alzheimer disease with exercise? About Alzheimer disease. Neurology, 2012. 78(17): p. e110-e112.
    12.
  12. Ruiz-Gonzalez, D., et al., Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: a systematic review and meta-analysis of randomized controlled trials. Neuroscience & Biobehavioral Reviews, 2021. 128: p. 394-405.
    13.
  13. Farina, N., Rusted, J., and Tabet, N. The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review. International Psychogeriatrics, 2014. 26(1): p. 9-18.
    14.
  14. Chapman, S.B., et al., Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Frontiers in aging neuroscience, 2013. 5: p. 75.
    15.
  15. Leem, Y.H., et al., Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. Journal of neuroscience research, 2009. 87(11): p. 2561-2570.
    16.
  16. Ebrahimi, K., et al., The effect of strength training on spatial learning and memory in Aβ rat model of Alzheimer's disease. medical scholar, 2016. 24(3): p. 9-18.
    17.
  17. Azevedo, C.V., et al., The effects of resistance exercise on cognitive function, amyloidogenesis, and neuroinflammation in Alzheimer’s disease. Frontiers in Neuroscience, 2023. 17: p. 1131214.
    18.
  18. Asgharzadeh, S. and Bigdeli, M. Medicinal herbs effective in the treatment of the Alzheimer’s disease. Journal of Babol University of Medical Sciences, 2015. 17(3): p. 51-59.
    19.
  19. Moghdisi, A., Adalat Manesh, F., & Mohammad Amin. (2019). The effect of eight weeks of moderate-intensity endurance training with saffron consumption on memory and learning in Alzheimer's mice model of trimethyltin. Journal of Applied Sports Physiology, 15(30), 115-128. p. 115-128.
    20.
  20. Milajerdi, A. and Mahmoudi, M. Review on the effects of saffron extract and its constituents on factors related to nervous system, cardiovascular and gastrointestinal diseases. JCE, 2014. 3(1): p. 108-127.
    21.
  21. Shamsi, M., Elmiyeh, A., and Shabani R, Strength-endurance exercises combined with olive oil consumption on motor function and oxidative stress level in the brain of male parkinsonian rats. Journal of Jiroft University of Medical Sciences, 2022. 9(2): p. 926-937.
    22.
  22. Eslimi Esfehani, D., et al., Effect of Fennel Extract on the Improvement of Memory Disorders in Beta Amyloid Alzheimer Model of Male Wistar Rats. Journal of Ilam University of Medical Sciences, 2019. 27(1): p. 1-12.
    23.
  23. Noshadi, E., et al., A Review of Mitochondrial Biogenesis and Cellular Response. The Scientific Journal of Iranian Blood Transfusion Organization, 2019. 16(2): p. 149-159.
    24.
  24. Seyedhosseini Tamijani, S.M., et al., Effect of three different regimens of repeated methamphetamine on rats’ cognitive performance. Cognitive Processing, 2018. 19(1): p. 107-115.
    25.
  25. Nazim, F., Salehi Kia, A., Marandi Seyed, M., Mushtaqian Seyed, J., & Rashid Kabali, A. The effect of resistance and combination exercises on biochemical markers of osteogenesis and bending strength of the femur of osteoprotic male rats..
    26.
  26. Nazari, M., Mahmoud, Sadraei, Seyed Homayun, & Kaka. (2020). The effect of low-frequency electromagnetic fields on motor activity and histomorphometry of the motor area of the frontal cortex in adult male rats. Cell and Tissue, 11(3), 167-177.
    27.
  27. Hosseinzadeh, S., Dabidi Roshan, V., and M. Pourasghar, Effects of intermittent aerobic training on passive avoidance test (shuttle box) and stress markers in the dorsal hippocampus of wistar rats exposed to administration of homocysteine. Iran J Psychiatry Behav Sci, 2013. 7(1): p. 37-44.
    28.
  28. Qarari Arefi, Saqib Jo, Hedayati, Fathi, & Rosita. (2016). The role of aerobic exercise and receiving omega-3 supplements on the level of phosphorylated tau protein in the hippocampus of Alzheimer's rats treated with homocysteine. Sports Physiology, 8(31), 171-188.
    29.
  29. Commenges, D., et al., Intake of flavonoids and risk of dementia. European journal of epidemiology, 2000. 16(4): p. 357-363.
    30.
  30. Ding, Q., et al., Exercise affects energy metabolism and neural plasticity‐related proteins in the hippocampus as revealed by proteomic analysis. European Journal of Neuroscience, 2006. 24(5): p. 1265-1276.
    31.
  31. miohsen khalili, n.a., et al., The effect of aqueous saffron extract on memory loss caused by intraventricular injection of streptozotocin in male rats.
    32.
  32. Wenk, G.L., An hypothesis on the role of glucose in the mechanism of action of cognitive enhancers. Psychopharmacology, 1989. 99: p. 431-438.
    33.
  33. Dao, A.T., et al., Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology. Current Alzheimer Research, 2013. 10(5): p. 507-515.
    34.
  34. Ebrahimi, Rihani Raad, Seddiq Dosin, & Watan Dost. (2016). The effect of strength training on memory and spatial learning in Alzheimer's rats treated with beta-amyloid. Daneshvar Medical, 24(3), 18-9
    35.
  35. De las Heras, N., et al., Chronic exercise improves mitochondrial function and insulin sensitivity in brown adipose tissue. Frontiers in physiology, 2018. 9: p. 1122.
    36.
  36. Hoffman-Goetz, L. and P. Spagnuolo, Effect of repeated exercise stress on caspase 3, Bcl-2, HSP 70 and CuZn-SOD protein expression in mouse intestinal lymphocytes. Journal of Neuroimmunology, 2007. 187(1-2): p. 94-101.
    37.
  37. Zhen, Y.F., et al., Low BDNF is associated with cognitive deficits in patients with type 2 diabetes. Psychopharmacology, 2013. 227: p. 93-100.
    38.
  38. Hosseinzadeh Hossein, & Ziyai Sayedeh Taktam. It is investigating the effect of saffron and its active substances, safranal and crocin, on healthy and destroyed memory with hyoscine on spatial learning in rats.
    39.
  39. Zhang, Y., et al., Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biological and Pharmaceutical Bulletin, 1994. 17(2): p. 217-221.
    40.
  40. Howes, M.J.R., N.S. Perry, and P.J. Houghton, Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2003. 17(1): p. 1-18.
    41.
  41. Tracy, T.E. and L. Gan, Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. Bioessays, 2017. 39(4).
    42.
  42. Rueb, U., et al., Alzheimer’s disease: characterization of the brain sites of the initial tau cytoskeletal pathology will improve the success of novel immunological anti-tau treatment approaches. Journal of Alzheimer's Disease, 2017. 57(3): p. 683-696.
    43.
  43. Leckie, R.L., et al., Omega-3 fatty acids moderate effects of physical activity on cognitive function. Neuropsychologia, 2014. 59: p. 103-111.
    44.
  44. 44. Bayod, S., et al., Long-term treadmill exercise induces neuroprotective molecular changes in rat brain. Journal of Applied Physiology, 2011. 111(5): p. 1380-1390.
    45.
  45. 45. Ohia-Nwoko, O., et al., Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Molecular neurodegeneration, 2014. 9: p. 1-17.
    46.

سکوی نشر دانش

سند یا سکوی نشر دانش ،سامانه ای جهت مدیریت حوزه علمی و پژوهشی نشریات دانشگاه آزاد می باشد

پیوندهای سایت

مراکز مرتبط

پشتیبانی

صفحات رسمی

حقوق این وب‌سایت متعلق به سامانه مدیریت نشریات دانشگاه آزاد اسلامی است.
حق نشر © 1403-1400

صفحه اصلی| عضویت/ ورود| درباره سند| تماس با ما|
[English] [العربية] [en] [ar]