Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent
محورهای موضوعی : Journal of Chemical Reactivity and Synthesis
1 - Department of Chemistry, School of Sciences, Ahvaz Branch, Islamic Azad University, Iran
کلید واژه: pyrimidine, thiazolo[4, 5-d]pyrimidine, 5-Bromo-2, 4-dichloro-6-methylpyrimidine, 4-Amino-5-bromo-2-substituted-aminopyrimidines,
چکیده مقاله :
4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives.
