One-Pot Synthesis of Phenytoin Analogs in soilution Conditions
محورهای موضوعی : Journal of Chemical Reactivity and Synthesis
Alireza Kiasat
1
(Department of Chemistry , Shahid Chamran University , Ahvaz , Iran)
Maryam Nikmanesh
2
(Department of Chemistry , Shahid Chamran University , Ahvaz , Iran)
کلید واژه: Green Chemistry, Synthesis, solvent free, Phenytoin, Grinding,
چکیده مقاله :
phenytoine derivatives were synthesized , via the pinacol condensation with thereaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thioureain presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle atroom temperatures. The reaction was completed at short reaction times (approximately15min) and pure products were obtained with high yields (81-94%).
