بررسی اثر عصاره گیاه کرفس (Apium graveolens) بر میزان کلسیم و اگزالات سرم در آسیب کلیوی ناشی از اتیلن گلیکول در موش‌های صحرایی نر بالغ نژاد ویستار
محورهای موضوعی : آسیب شناسی درمانگاهی دامپزشکیپریسا مهرپرور 1 , اکرم عیدی 2 , سید پژمان مرتضوی 3 , شهربانو عریان 4
1 - گروه زیست شناسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
2 - گروه زیست شناسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
3 - دانشیار پاتولوژی، گروه پاتولوژی دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران.
4 - گروه زیست شناسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
کلید واژه: موش صحرایی, کرفس, سنگ‌کلیه, اتیلن گلیکول,
چکیده مقاله :
کرفس (Apium graveolens) گیاهی دوساله و از خانواده Apiaceae است. بخش های مختلف کرفس در اختلالات کبدی و طحال، اختلالات مغزی، درد و اختلالات خواب استفاده می شود. مطالعه حاضر به منظور بررسی اثر عصاره اتانولی کرفس بر آسیب کلیه ناشی از اتیلن گلیکول در موش های صحرایی نر نژاد ویستار انجام گرفت.القاء سنگ کلیه با استفاده از تیمار 75/0 درصد اتیلن گلیکول به مدت 28 روز انجام شد. موش ها به 8 گروه 6تایی تقسیم شدند که به ترتیب شامل کنترل سالم، کنترل سنگ کلیوی (75/0 درصد اتیلن گلیکول در آب آشامیدنی)، حیوانات سالم تیمار با عصاره کرفس در دوزهای 50، 100 و 200 میلی گرم بر کیلوگرم و موش های سنگ کلیویتیمار با عصاره کرفس در دوزهای 50، 100 و 200 میلی گرم در کیلوگرم وزن بدن به صورت گاواژ بودند. در پایان آزمایش (28 روز)، نمونه خون از قلب موش ها جمع آوری شد و میزان کلسیم و اگزالات در سرم ارزیابی گردید. واکاوی آماری از طریق آزمون تحلیل واریانس یک طرفه و آزمون تعقیبی توکی انجام شد و 05/0p< معنی دار در نظر گرفته شد.افزایش معنی دار میزان اگزالات و کاهش معنی دار کلسیم سرم در حیوانات گروه کنترل سنگ کلیوی در مقایسه با گروه کنترل سالم مشاهده شد. تیمار عصاره کرفس با غلظت 200 میلی گرم بر کیلوگرم وزن بدن باعث کاهش معنی دار اگزالات و افزایش معنی دار کلسیم سرم در حیوانات دچار سنگ کلیوی شد.نتایج مطالعه حاضر نشان داد که عصاره کرفس می تواند باعث بهبود سنگ کلیه ناشی از اتیلن گلیکول شود.
چکیده انگلیسی:
Celery (Apium graveolens) is a biennial plant, belonging to family Apiaceae. Various parts of celeryare used in hepatic and spleen disorders, brain disorders, body pain, and sleep disturbances. The present study was planned to investigate the effect of celery ethanolic extract on ethylene glycol induced kidney injury in male Wistar rats. Urolithiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol for 28 days. Animals were divided into 8 groups (n=6) including normal control, urolithiatic control (0.75% ethylene glycol in their drinking water), normal rats receiving celery extract at doses of 50, 100 and 200 mg/kg and urolithiatic rats receiving celery extract at doses of 50, 100 and 200 mg/kg intragastrically. At the end of the experiment (28 days), blood samples were collected by cardiac puncture and serum calcium and oxalate was analyzed. Statistical analysis was performed by one-way analysis of variance followed by Tukey post hoc test (p<0.05). Significant elevation of serum oxalate and reduction of serum calcium was observed in urolithiatic control rats compared with the normal control rats. Administration of celery extract at a dose of 200 mg/kg produced significant elevation in serum calcium and reduction in serum oxalate in urolithiatic rats. Thus, celery extract could ameliorate urolithiasis induced by ethylene glycol.
منابع و مأخذ:
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Calixto, J.B., Beirith, A., Ferreira, J., Santos, A.R.S., Cechinel Filbo, V. and Yunes, R.A. (2000). Naturally occurring antinociceptive substances from plants. Phytotherapy Research, 14: 401-418.
Cao, Z.G., Liu, J.H., Zhou, S.W., Wu, W., Yin, C.P. and Wu, J.Z. (2004). The effects of the active constituents of Alisma orientalis on renal stone formation and bikunin expression in rat urolithiasis model. Zhonghua Yi Xue Za Zhi, 84(15): 1276-1279.
Choochote, W., Tuetun, B., Kanjanapothi, D., Rattanachanpichai, E., Chaithong, U., Chaiwong, P., et al. (2004). Potential of crude seed extract of celery, Apium graveolens L., against the mosquito Aedes aegypti (L.) (Diptera: Culicidae). Journal of Vector Ecology: Journal of the Society for Vector Ecology, 29(2): 340-346.
Corley, R.A., Bartels, M.J., Weitz, K.K., Soelberg, J.J., Gies, R.A. and Thrall, K.D. (2005). Development of a physiologically based pharmacokinetic model for ethylene glycol and its developmentally toxic metabolite, glycolic acid, in adult rats and humans. Toxicological Sciences, 85: 476-490.
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Curhan, G.C., Willett, W.C., Knight, E.L. and Stampfer, M.J. (2004). Dietary factors and the risk of incident kidney stones in younger women. Nurses’ health study II. Archives of Internal Medicine, 164(8): 885-891.
Dong, W., Wei, T., Guang-Ming, Y. and Bao-Chang, C. (2010). Anti-inflammatory, antioxidant and cytotoxic activities of flavonoids from Oxytropis falcata Bunge. Chinese Journal of Natural Medicines, 8(6): 461-465.
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Hardani, A., Afzalzadeh, M.R., Amirzargar, A., Mansouri, E. and Meamar, Z. (2015). Effects of aqueous extract of celery (Apium graveolens L.) leaves on spermatogenesis in healthy male rats. Avicenna Journal of Phytomedicine, 5(2): 113-119. [In Persian]
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Arumuham, V. and Bycroft, J. (2016). The management of urolithiasis. Surgery, 34(7): 352-360.
Ahmed, Q.S. and Sayedda, K. (2012). Effect of celery (Apium graveolens) seeds extract on protease inhibitor (Ritonavir) induced dyslipidemia. National Journal of Integrated Research in Medicine, 3(1): 52-56.
Al-Howiriny, T., Alsheikh, A., Alqasoumi, S., Al-Yahya, M., ElTahir, K. and Rafatullah, S. (2010). Gastric antiulcer, antisecretory and cytoprotective properties of celery in rats. Pharmaceutical Biology, 48(7): 786-793.
Al-Snafi, A.E. (2014). The pharmacology of Apium graveolens. A review. International Journal for Pharmaceutical Research Scholars, 3(1-1): 671-677.
Aquila, S., Giner, R.M., Recio, M.C., Spegazzini, E.D. and Ríos, J.L. (2009). Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots. Journal of Ethnopharmacology, 121(2): 333-337.
Asif, H.M., Akram, M., Usmanghani, K., Akhtar, N., Shah, P.A., Uzair, M., et al. (2011). Monograph of Apium graveolens Linn. Journal of Medicinal Plant Research, 5(8): 1494-1496.
Baananou, S., Bouftira, I., Mahmoud, A., Boukef, K., Marongiu, B. and Boughattas, N.A. (2013). Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract. Natural Product Research, 27(12): 1075-1083.
Belanger, J.T. (1998). Perillyl alcohol: applications in oncology. Alternative Medicine Review, 3(6): 448-457.
Bos, R. and Fischer, F.C. (1986). Composition of the volatile oils from the roots, leaves and fruits of different taxa of Apium graveolens. Planta Medica, 6: 531.
Calixto, J.B., Beirith, A., Ferreira, J., Santos, A.R.S., Cechinel Filbo, V. and Yunes, R.A. (2000). Naturally occurring antinociceptive substances from plants. Phytotherapy Research, 14: 401-418.
Cao, Z.G., Liu, J.H., Zhou, S.W., Wu, W., Yin, C.P. and Wu, J.Z. (2004). The effects of the active constituents of Alisma orientalis on renal stone formation and bikunin expression in rat urolithiasis model. Zhonghua Yi Xue Za Zhi, 84(15): 1276-1279.
Choochote, W., Tuetun, B., Kanjanapothi, D., Rattanachanpichai, E., Chaithong, U., Chaiwong, P., et al. (2004). Potential of crude seed extract of celery, Apium graveolens L., against the mosquito Aedes aegypti (L.) (Diptera: Culicidae). Journal of Vector Ecology: Journal of the Society for Vector Ecology, 29(2): 340-346.
Corley, R.A., Bartels, M.J., Weitz, K.K., Soelberg, J.J., Gies, R.A. and Thrall, K.D. (2005). Development of a physiologically based pharmacokinetic model for ethylene glycol and its developmentally toxic metabolite, glycolic acid, in adult rats and humans. Toxicological Sciences, 85: 476-490.
Corley, R.A., Wilson, D.M., Hard, G.C., Stebbins, K.E., Bartels, M.J., Soelberg, J.J., et al. (2008). Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity. Toxicology and Applied Pharmacology, 228(2): 165-178.
Curhan, G.C., Willett, W.C., Knight, E.L. and Stampfer, M.J. (2004). Dietary factors and the risk of incident kidney stones in younger women. Nurses’ health study II. Archives of Internal Medicine, 164(8): 885-891.
Dong, W., Wei, T., Guang-Ming, Y. and Bao-Chang, C. (2010). Anti-inflammatory, antioxidant and cytotoxic activities of flavonoids from Oxytropis falcata Bunge. Chinese Journal of Natural Medicines, 8(6): 461-465.
Ebadi, M. (2007). Pharmacodynamic basis of herbal medicine. CRC Press, Taylor and Francis Group, pp: 89.
Fan, J., Glass, M.A. and Chandhoke, P.S. (1998). Effect of castration and finasteride on urinary oxalate excretion in male rats. Urological Research, 26(1): 71-75.
Feleming, T. (2000). PDR for herbal medicines. New Jersey: Montvale, NJ: Medical Economic Company, pp: 128-129, 173.
Fluke, H. (2005). Medicinal Plants. 6th ed., Tavakoli-Saberi, M., Sedaghat, R., translators. Iran: Tehran, Gulshan Press, pp: 201. [In Persian]
Fouad, A.A., Albuali, W.H., Zahran, A. and Gomaa, W. (2014). Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats. Environmental Toxicology and Pharmacology, 38(2): 420-429.
Gara, S.K., Gupta, S.R. and Sharma, N.D. (1980). Glucosides of Apium graveolens. Planta Medica, 38(4): 363-365.
Ghodasara, J., Pawar, A., Deshmukh, C. and Kuchekar, B. (2010). Inhibitory effect of rutin and curcumin on experimentally-induced calcium oxalate urolithiasis in rats. Pharmacognosy Research, 2(6): 388-392.
Hadjzadeh, M., Khoei, A., Hadjzadeh, Z. and Parizady, M. (2007). Ethanolic extract of Nigella sativa L. seeds on ethylene glycol-induced kidney calculi in rats. Urology Journal, 4(2): 86-90.
Hardani, A., Afzalzadeh, M.R., Amirzargar, A., Mansouri, E. and Meamar, Z. (2015). Effects of aqueous extract of celery (Apium graveolens L.) leaves on spermatogenesis in healthy male rats. Avicenna Journal of Phytomedicine, 5(2): 113-119. [In Persian]
He, X., Li, C., Wei, Z., Wang, J., Kou, J., Liu, W., et al. (2016). Protective role of apigenin in cisplatin-induced renal injury. European Journal of Pharmacology, 789: 215-221.
Heim, K.E., Tagliaferro, A.R. and Bobilya, D.J. (2002). Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. The Journal of Nutritional Biochemistry, 13(10): 572-584.
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