Dynamic light scattering: A useful technique to characterize nanoparticles
محورهای موضوعی : Journal of Nanoanalysis
Abbas Rahdar
1
(Department of Physics, University of Zabol, Zabol, Iran)
Nooshin Amini
2
(Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS),
Tehran, Iran)
Faezeh Askari
3
(Department of Physics, University of Zabol, Zabol, Iran)
Md. Susan
4
(Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh)
کلید واژه: Diffusion, Zeta Potential, Nanomedicine, Dynamic Light Scattering, Hydrodynamic Size, Surface Charge,
چکیده مقاله :
Biologically, two parameters of size and surface charge of the nanoparticles, especially therapeutic nanoparticles influence their kinetics in vivo as well as their interaction with the cellular and biological membranes and resulting their efficacy. So effective characterization of nanomaterials including nanometer-sized particles and micelles is a key issue to develop the well-deserved and well-defined Nano-formulations focus on the therapeutic goals in nanomedicine research. Determining the particle size and surface charge of nanoparticles are essential to characterize therapeutic nanoparticles properly. Measurements related to techniques of dynamic light scattering (DLS) and zeta potential (ZP) are known as easy, simple, and reproducible tools to obtain the size and surface charge of nanoparticles. Regarding characterization of particle size and surface charge by the DLS and ZP there is challenges for researchers to interpret and analyze the exported data effectively due to lack of adequate understanding focus on physical principles governing on the operating system of these techniques and how preparing samples for characterization and so on. With this in mind, this review tries to address this issue focus on the fundamental principles governing on techniques of DLS and ZP to better analyzing and interpreting the reported results such as hydrodynamic size, diffusion, inter particular interactions as well as study of the colloidal system stability based on surface charge of nanoparticles.
[1] L. Treuel, K.A. Eslahian, D. Docter, T. Lang, R. Zellner, K. Nienhaus, M. Maskos, Physicochemical characterization of nanoparticles and their behavior in the biological environment, Phys. Chem. Chem. Phys., 16, 15053 (2014). doi:10.1039/c4cp00058g
[3] F. Varenne,, Rustique, E, Botton, J, Coty, J B, Lanusse, G, Lahcen, M A, Negri L., Towards quality assessed characterization of nanomaterial: Transfer of validated protocols for size measurement by dynamic light scattering and evaluation of zeta potential by electrophoretic light scattering ,Int. J. Pharm., 528, 299 (2017). doi:10.1016/j.ijpharm.2017.06.006
[14] S. Bhattacharjee, I. M. Rietjens, M.P. Singh, T. M. Atkins, T. K. Purkait, Z. Xu, G. M. Alink, Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges, Nanoscale, 5, 4870 (2013). doi: 10.1039/c3nr34266b
[24] J. D. Clogston, R. M. Crist, S. E. McNeil, Cham, 187 (2016).
[33] C. Fleischer, C. K. Payne, Acc Chem Res., 47, 2651 (2017).
[42] A. Rahdar, M. Almasi-Kashi, Entrapment–D-(+)-Glucose Water Nanodroplet: Synthesis and Dynamic Light Scattering, J Nanostruct, 8, 202 (2018).doi: 10.22052/JNS.2018.02.010
[53] X. Zhao, S. Zhu, Y. Song, J. Zhang, B.Yang, Photoluminescent graphene quantum dots for in vitro and in vivo bioimaging using long wavelength emission, RSC Adv., 5, 15187 (2015). doi: 10.1039/C5RA02961A