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عنوان URL للمقالة


رقم المقالة : 533432 زيارة : 106 الصفحة: 85 - 94

10.22034/aej.2017.533432

نوع المخطوط: ابحاث

اثر عصارۀ بذر گزنه و شنبلیله بر موش سوری دیابتی شده

الموضوعات : بوم شناسی گیاهان زراعی

امید علیزاده 1 , حسن نورافکن 2 , اسد اسدی 3

1 - گروه علوم باغبانی، واحد میانه، دانشگاه آزاد اسلامی، میانه، ایران
2 - باشگاه پژوهشگران جوان و نخبگان، واحد میانه، دانشگاه آزاد اسلامی، میانه، ایران
3 - مرکز تحقیقات کشاورزی و محصولات ارگانیک، دانشکده کشاورزی، واحد میانه، دانشگاه آزاد اسلامی، میانه، ایران

تاريخ الإرسال : 16 الجمعة , شعبان, 1438 تاريخ التأكيد : 11 السبت , ذو الحجة, 1438 تاريخ الإصدار : 01 الأربعاء , ذو الحجة, 1438

الکلمات المفتاحية:  استرپتوزوتوسین,  آنتی‌اکسیدان,  کلسترول,  گلوکز خون,  لیپوپروتئین,

ملخص المقالة :

به منظور ارزیابی اثر عصارۀ بذر گزنه و شنبلیله بر گلوکز، شاخص های چربی و تنش اکسیداتیو در موش سوری دیابتی شده با استرپتوزوتوسین، 40 سر موش سوری نر نژاد NMRI، در گروه های پنج تایی مطالعه شدند. تیمارها شامل ده بار تزریق به صورت روزانه با مت فورمین، عصارۀ بذر گزنه، شنبلیله و ترکیب آنها به نسبت های 1:4، 2:4 و 3:4 به همراه شاهد مثبت و منفی بودند. پس از 48 ساعت از آخرین تزریق، از طریق خون‌گیری داخل بطنی میزان گلوگز، کلسترول، لیپوپروتئین با چگالی بالا و پایین و ظرفیت تام آنتی اکسیدان سرم اندازه گیری شد. تیمارهای آزمایشی به ویژه عصارۀ ترکیبی بذر گزنه و شنبلیله به نسبت 2:4 موجب کاهش میزان گلوکز خون شد. عصارۀ ترکیبی با نسبت 1:4، میزان کلسترول را به شکل قابل توجهی کاهش داد ولی مت فورمین و عصارۀ بذر گزنه باعث افزایش آن گردید. عصارۀ بذر گزنه باعث افزایش میزان لیپوپروتئین با چگالی بالا و عصارۀ ترکیبی موجب کاهش میزان آن گردید. گزنه و مت فورمین باعث افزایش میزان لیپوپروتئین با چگالی پایین خون گردید. مت فورمین، عصارۀ بذر گزنه و عصاره ترکیبی با نسبت 2:4 باعث افزایش ظرفیت تام آنتی اکسیدانی سرم گردید. بنابراین، عصاره های مورد بررسی، می توانند به عنوان گزینه ای در درمان دیابت و کاهش عوارض ناشی از آن مطرح باشند.

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_||_

  1. Ahangarpour A, Mohammadian M, Dianat M (2012) Antidiabetic effect of hydroalcholic Urtica dioica leaf extract in male rats with fructose-induced insulin resistance. Iranian Journal of Medicinal Science 37(3): 181–186.
    2.
  2. Andreoli T, Fitz G, Wing JE, Griggs R, Benjamin I (2010) Andreoli and carpenter's Cecil essentials of medicine, 8th Edition. Arjmand Ppublishing: Tehran. [in Persian]
    3.
  3. Bathaie SZ, Mokarizade N, Shirali S (2012) An overview of the mechanisms of plant ingredients in the treatment of diabetes mellitus. Journal of Medicinal Plants 11(44): 1-25. [n Persian with English abstract]
    4.
  4. Behradmanesh M, Ahmadi M, Rafieian-kopaei M (2012) Effect of glycogol on blood glucose level of patients with type II diabetes. Iranian Journal of Endocrinology and Metabolism 14(2):163-169. [in Persian with English abstract]
    5.
  5. Chandra Joshi B, Mukhija M, Semwal S (2015) Antioxidant potential and total phenolic content of Urtica dioica (whole plant). Journal of Applied Pharmacy 7(2):120-128.
    6.
  6. Farhadi A, Esmaeili R, Pourashraf A, Azizi B (2011) Effect of nettle on diabetes. Proceedings of the First National Conference on Economic in Agriculture and Natural Resources. Qom, Iran. [in Persian]
    7.
  7. Heshmati H, Behnampour N, Khorasani F, Mogadam Z (2013) The prevalence of chronic complications of diabetes and its related factors in type 2 diabetic patients referring to diabetes center of Fereydounkenar. Journal of Neyshabur University of Medical Sciences 1(1): 36-43. [in Persian]
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  9. Kasaeian N, Forgani B, Zare M, Tajolmoluk E, Amini M (2003) Effect of fenugreek seed uses on fasting blood glucose, glycosylated hemoglobin and blood fats in diabetic type 2 patients. Medical Journal of Tabriz University of Medical Sciences 37(58): 55-58. [in Persian]
    10.
  10. Kanter M, Meral I, Dede S, Gunduz H, Cemek M, Ozbek H, Uygan I (2003) Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats. Journal of Veterinary Medicine: A, Physiology, Pathology, Clinical Medicine 50(5): 264-268.
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    12.
  12. Kamakhya K, Shiv K, Arunima D, Arup B (2015) Effect of fenugreek seeds on glycaemia and dyslipidemia in patients with type 2 diabetes mellitus. International Journal of Medical Science and Public Health 4(7):997-1000.
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  20. Mahjoub S, Davari S, Moazezi Z, Qujeq D (2012) Hypolipidemic effects of ethanolic and aqueous extracts of Urtica dioica in rats. World Applied Sciences Journal 17(10): 1345-1348.
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  31. Olorunnisola OS, Bradley G, Afolayan AJ (2012) Effect of methanolic extract of Tulbaghia violacea rhizomes on antioxidant enzymes and lipid profile in normal rats. African Journal of Pharmacy and Pharmacology 6(14): 1026-1030.
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    35.
  35. Qujeq D, Davary S, Moazzi Z, Mahjoub S (2011) Effect of Urtica dioica leaf extract on activities of nucleoside diphosphate kinase and acetyl coenzyme, a carboxylase, in normal and hyperglycemic rats. African Journal of Pharmacy and Pharmacology 5(6): 792–796.
    36.
  36. Rafraf M, Malekian M, Asghari Jafar Abadi M, Ali Asgarzadeh A, Pourmordian S (2015) Effect of fenugreek seeds on serum metabolic factors and ICAM-1 (Intercellular adhesion molecule1) levels in type 2 diabetic patients. Journal of Research in Medical Sciences University of Iran 32(69): 11-21. [in Persian with English abstract]
    37.
  37. Rajeev G, Verma S (2015) Study of effects of consumption of powdered fenugreek seeds on serum lipid profile in patients with type 2 diabetes mellitus. International Journal of Biomedical and Advance Research 6(01): 57-59.
    38.
  38. Ranjbar Omidi B, Armaz F, Agaei M (2012) Effect of dietary fiber (wheat bran) on fasting blood glucose after diet in people with fasting diabetes mellitus. Scientific Journal of the Student Research Committee of Qazvin University 7(26): 26-32. [in Persian]
    39.
  39. Ranjbari A, Azarbayjani MA , Yusof A, Abdul Halim M, Akbarzadeh S, Ibrahim Mohamed Y, Tarverdizadeh B, Farzadinia P, Hajiaghaee R, Dehghan F (2016) In vivo and in vitro evaluation of the effects of Urtica dioica and swimming activity on diabetic factors and pancreatic beta cells. Biomed Central Complementary and Alternative Medicine 16(101):12906-12916.
    40.
  40. Roghani M, Baluchnejad mojarad T, Roghani Dehlordi F (2005) Hypolipidemic effect of aqueous leaf extract of Trigonella foenum-graecum in diabetic rats. Iranian Journal of Endocrinology and Metabolism 7(2): 167-171. [in Persian with English abstract]
    41.
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