Background & Aim: One of the major problems of modern medicine is the increasing consumption of synthetic drugs and frequent use of them will result in side effects. Considering this issue, patients should be mainly motivated to use pharmaceutical plants. Regarding the positive effects of sumac on the immune system, in the present study, we made a decision to compare sumac with levamisole as a chemical immune system stimulant compound. Experimental: In this research, 8 native breed of dogs were studied for ten days. The dogs were divided into four groups of two including a control group, a group consuming levamisole, a group consuming the amount of 10 mg per kg sumac, and a group receiving 5 mg per kg sumac. Then, blood samples were taken and the relevant tests were performed after completing the period of intaking the prescribed amount of powders of sumac plant and oral levamisole. Results: According to present results, significant differences were observed between treatment and control groups in terms of some factors including phagocytosis, multiplicity of phagocytosis mass and IGM whereas there was no significant difference in other factors (p < 0.05). It was revealed that sumac plant same as levamisole can increase immunity and phagocytosis in dogs. Recommended applications/ industries: In present study, considering the significant positive effects of sumac on some immunological parameters, this herb is recommended to be prescribed in the food. تفاصيل المقالة