Background and Aim: Since prior to any research on the drugs, it should be aware of its allergic dose, and considering the importance of hematological system, which reveals the changes in the body, in this study, we decided to investigate the hematologic effects of sumac plant and compare it with a chemical agent (levamisole). Therefore, in future studies, it will be used with confidence of its valuable properties especially antibacterial effects and may be replaced with some drugs, including levamisole. Experimental: In this study, 8 native breed dogs were tested for ten days. They were divided into four groups of two, which included the control group, the group receiving levamisole, the group receiving the sumac at a dose of 10 mg/kg, and the group receiving the sumac at a dose of 5 mg/kg. After the end of the period of sumac and levamisol powder administration, blood samples were taken and then the related tests were carried out. Results and Discussion: Given that in most allergies and poisoning, there is an increase in eosinophils and basophils, as well as red blood cell lysis, and also decrease in hematocrit can be observed, and because no studies have been conducted so far on allergic factors such as eosinophils and basophils, there was no significant difference between treatment and control group (p>0.05) in the dose of sumac used in this study. So the lack of allergy to this plant is assured. Industrial and Practical recommendation: According to the same hematologic results of sumac plant and levamisole obtained in this study, it is possible to use the valuable properties of the sumac plant, especially the antimicrobial and immune plus effects in future studies, without worrying about allergic reactions and hematologic side effects at the dose specified in this study. تفاصيل المقالة