مقدمه: چاقی و اضافه‌وزن، عمومی‌ترین بیماری متابولیک در جهان و عامل ایجادکننده یا تشدیدکننده بسیاری از بیماری‌هاست؛ که با کاهش کیفیت زندگی همراه است. تمرینات ورزشی باعث افزایش چگالی مویرگی عضله اسکلتی می‌شود؛ اما مکانیسم مولکولی این فرایند هنوز به‌طور کامل مشخص نیست، ازاین‌رو هدف پژوهش حاضر تعیین تأثیر هشت هفته مقاومتی دایره‌ای بر VEGF و شاخص‌های آتروژنیک در مردان چاق بود. مواد و روش‌ها: در این مطالعه شبه تجربی، 22 مرد با 3 BMI=30±کیلوگرم بر مترمربع به‌طور داوطلبانه در این تحقیق شرکت کردند که به‌طور تصادفی به دو گروه کنترل و تمرین مقاومتی دایره‌ای (11 نفر) تقسیم شدند. برنامه‌ی تمرین مقاومتی شامل ۳ جلسه در هفته و به مدت هشت هفته با شدت تمرین بین 60 تا 80 درصد یک تکرار بیشینه بود. نمونه‌های خون سیاهرگی که در مراحل پیش‌آزمون و پس‌آزمون گرفته‌شده بودند برای سنجش VEGF و شاخص‌های آتروژنیک مورداستفاده قرار گرفت. تحلیل داده‌ها توسط آزمون‌ ANOVA با اندازه‌گیری مکرر و با استفاده از نرم‌افزار SPSS نسخه 23 انجام شد. یافته‌ها: نتایج نشان داد که سطوح سرمی VEGF از 75/1628 به 93/1762 (pg/ml) افزایش یافت که این افزایش در گروه تمرین نسبت به گروه کنترل معنی‌دار بود (001/0p<). همچنین نسبت LDL/HDL، TC/HDL و TG/HDL نیز در گروه تمرین نسبت به گروه کنترل به‌طور معنی‌داری کاهش یافت (001/0p<). نتیجه‌گیری: با توجه به اثرات مطلوب تمرین مقاومتی دایره‌ای بر سطح سرمی VEGF همچنین نسبت LDL/HDL، TC/HDL و TG/HDL ممکن است، شرایط متابولیکی افراد دارای اضافه‌وزن و چاق را بهبود ببخشد. تفاصيل المقالة

Introduction: Hypertension is one of the common diseases in modern societies. ANP hormone is one of the factors regulating blood pressure. Apart from conventional clinical treatments, recent attention has been paid to the impact of exercise on ANP. But there is still debate around the type of exercise that is being used. Therefore, the aim of this study was to investigate the effect of aerobic and resistance training on gene expression and protein levels of ANP in male Wistar rats.
Methods: In this experimental study, 15 male Wistar rats were divided into 3 groups of 5 subjects including (1) control, (2) aerobic training, and (3) resistance training. Aerobic training included running on treadmill at 20 m/min (5 sessions, each session 60 minutes per week), while resistance training included climbing a ladder of one meter with 85-degree slope. For analyzing the findings, one-way ANOVA with Tukey's post hoc test were run using SPSS version 19 (p<0.05). Results: aerobic training had a significant effect on the increased levels of the ANP gene expression (p = 0.001) and ANP tissue concentration (p = 0.001) in the heart tissue of rats. Resistance training had a significant effect on the increased levels of ANP gene expression (p = 0.001) and ANP tissue concentration (p = 0.001) in the heart tissue of rats. Also, aerobic training had a greater effect on the ANP gene expression and ANP tissue concentration in the heart tissue of rats compared to resistance training (p = 0.001). Conclusion: It seems that aerobic and resistance training with a significant increase in ANP gene expression and ANP concentration, elevate heart health, however, the effect of aerobic training in this field was more than resistance training. تفاصيل المقالة

Introduction: Adhesive molecules of cellular markers have been applied to identify the process of formation of atherosclerotic plaque of vascular endothelial wall. The present research aimed to evaluate the effect of continuous and interval aerobic trainings on body mass index and serum levels of ICAM-1 and VCAM-1 in men with heart failure. Methods: In the present research, 42 middle-aged men with heart failure were purposefully and randomly divided to three equal groups (each 14 participants) including continuous, periodic, and control aerobic exercises. Continuous exercise (with the intensity of 45-70% maximum heart rate) and periodic exercises (with the intensity of 45-80% of MHR) were done for 3 days a week, with a total term of 8 weeks. Before and after the implementation of the exercise plan, blood samples were taken from three groups. Data were analyzed by one-way ANOVA (P≤0.05). Results: Comparison of mean of intra-group indicated a significant decrease in the level of cellular adhesion molecule-1 and vascular adhesion molecules-1 and body mass index in the exercise groups (P≤0.05). In Intragroup comparison, the two groups of exercise, VCAM-1(P=0.0001) and body mass index (P=0.002) were significantly decreased, but no significant change was observed in ICAM-1(P=0.107). Decrease in VCAM-1 levels and BMI between the two exercise groups were more significant than the control group, but there was no significant difference between the two groups of periodic and aerobic. Conclusion: With decreasing BMI and VCAM-1 levels, aerobic exercises may have a significant role in the prevention and control of cardiovascular disease in patients with heart failure. تفاصيل المقالة