Investigation of the release kinetics of strong optical photosensor Hypericin from Poly (e-caprolacton) nanofibrous mat

Subject Areas :

محمودرضا سهرابی ¹ (استاد شیمی تجزیه، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران)
فائقه پورحجت ² (دانشجوی دکترای شیمی کاربردی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران)
شهاب شریعتی ³ (دانشیار شیمی تجزیه، دانشگاه آزاد اسلامی واحد رشت، دانشکده علوم پایه، رشت، ایران)

Received: 2017-04-07 Accepted : 2018-01-08 Published : 2018-05-22

Keywords: Antibacterial, Electrospinning, Polymeric Nanofibers, Release Test, Poly (Ɛ-caprolacton,

Abstract :

Transdermal drug delivery systems with controlled release are a useful device for local transfer of pharmaceutical components to the damaged site and healthy layers of the skin. These devices are particularly suitable for wound healing in cases where long-term treatment and frequent wound dressing exchange are needed. In this research, due to the superior feature of nanofibers, high surface to volume ratio, electrospinning technique was used to make dressings, for antimicrobial photodynamic therapy (aPDT), using biocompatible and biodegradable polymers such as poly (Ɛ-caprolactone) (PCL). Optimized conditions (voltage, flow rate nozzle to collector distance rotation) for obtaining nanofibers PCL/Extract (10, 30, 50%V/V) are as follows: Voltage of 12kV for nanofibers PCL and PCL-E50, and 20kV for PCL-E10 and PCL-E30, flow rate of 0.1ml/h for PCL and PCL-E50, and 0.5 ml/h for PCL-E10 and PCL-E30, and distance of 100 mm for all the nanofibers.

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