Evaluation of oxidative stress in cattle with subclinical ketosis and clinical endometritis
Subject Areas :
Veterinary Clinical Pathology
farhad Balari Mahyari
1
(D.V.M. Graduate, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.)
maryam karimi dehkordi
2
(Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.)
mohammadreza nazem
3
(Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.)
Received: 2019-05-04
Accepted : 2020-01-07
Published : 2020-01-21
Keywords:
dairy cattle,
subclinical ketosis,
Oxidative status,
Clinical endometritis,
Abstract :
Today, the most important factor in the occurrence of metabolic and reproductive diseases in dairy cattle is the disturbance of natural process in body’s cellular-molecular events that occur after increasing of oxidants and the formation of oxidative stress. The aim of this study was to evaluate the possibility of a significant association between the serum concentrations of malondialdehyde (MDA) and total antioxidant capacity (TAC), as oxidative stress indexes, with the incidence of subclinical ketosis and clinical endometritis in dairy cows. For this purpose, 101 Holstein dairy cows were divided into 4 groups (healthy, subclinical ketosis, clinical endometritis, and both of them subclinical ketosis-clinical endometritis), and serum levels of MDA and TAC were measured in one month before delivery. The lowest serum concentration of TAC and the highest plasma MDA levels were observed in cows with both of diseases, while control group (healthy cows) had the highest serum concentration of TAC and lowest MDA levels (P≤0.05). There was no significant difference in serum concentrations of TAC and MDA between clinical endometritis and subclinical ketosis groups (p>0.05). The results of this study demonstrated a significant correlation between serum concentrations MDA and TAC with the incidence of clinical endometritis and prevalence of ketosis-endometritis in dairy cows (P≤0.05). Conflict of interest: None declared.Keywords: Malondialdehyde, Total Antioxidant Capacity, Clinical Endometritis, Subclinical Ketosis.
References:
Adly, A.A. (2010). Oxidative stress and disease: An updated review. Research Journal of Immunology, 3(2): 129-145.
Albera, E. and Kankofer, M. (2010). The comparison of antioxidative/oxidative profile in colostrum, milk and blood of early post-partum cows during their first and second lactation. Reproduction in Domestic Animals, 45(6): 417-25.
Al-Qudah, K. (2011). Oxidant and antioxidant profile of hyperketonemic ewes affected by pregnancy toxemia. Veterinary Clinical Pathology, 40(l): 60-65.
Andersson, L. (1988). Subclinical ketosis in dairy cows. Veterinary Clinics of North America: Food Animal Practice, 4(2): 233-251.
Baithalu, R.K., Singh, S.K., Kumaresan, A., Mohanty, A.K., Mohanty, T.K., Kumar, S., et al. (2017). Transcriptional abundance of antioxidant enzymes in endometrium and their circulating levels in Zebu cows with and without uterine infection. Animal Reproduction Science, 177: 79-87.
Benzie, I.F. and Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry, 239(1): 70-76.
Bernabucci, U., Ronchi, B., Lacetera, N. and Nardone, A. (2017). Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science, 88(6): 2017-2026.
Birben, E., Sahiner, U.M., Sackesen, C., Erzurum, S. and Kalayci, O. (2012). Oxidative Stress and Antioxidant Defense. World Allergy Organization Journal, 5(1): 9-19.
Caldecott, K.W. (2003). Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31(1): 247-251.
Castillo, C., Hernandez, J., Valverde, I., Pereira, V., Sotillo, J., Alonso, M.L., et al. (2006). Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Research in Veterinary Science, 80(2): 133-139.
Celi, P. (2010). The role of oxidative stress in small ruminant health and production. Revista Brasileira de Zootecnia, 39: 348-363.
Celi, P. and Gabai, G. (2015). Oxidant/antioxidant balance in animal nutrition and health: the role of protein oxidation. Frontiers in Veterinary Science, 2(48): 1-13.
Di Trana, A., Celi, P., Claps, S., Fedele, V. and Rubino, R. (2006). The effect of hot season and nutrition on the oxidative status and metabolic profile in dairy goats during mid-lactation. Animal Science, 82(5): 717-722.
EL-Bahr, S.M. and EL-Deeb, W.M. (2017). Oxidative stress and cardiac biomarkers in lambs affected with enzootic ataxia: the diagnostic and prognostic significance. Veterinarski Arhiv, 87(3): 259-271.
Hanafi, E.M., Ahmed, W.M., Abd El Moez, S.I., El Khadrawy, H.H. and Abd El Hameed, A.R. (2008). Effect of clinical endometritis on ovarian activity and oxidative stress status in Egyptian buffalo-cows. Journal of Agricultural, Food and Environmental Sciences, 4(5): 530-536.
Heidarpour, M., Mohrı, M., Fallah-Rad, A.H., Shahreza, F.D. and Mohammadi, M. (2012). Oxidative stress and trace elements before and after treatment in dairy cows with clinical and subclinical endometritis. Revue de Médecine Vétérinaire, 163(12): 628-633.
Herdt, T.H. (2000). Ruminant adaptation to negative energy balance. Veterinary Clinics of North America: Food Animal Practice, 16(2): 215-230.
Jain, S.K., McVie, R. and Bocchini, J.A. (2006). Hyperketonemia (ketosis), oxidative stress and type 1 diabetes. Pathophysiology, 13(3): 163-70.
Karimi, N., Mohri, M., Seifi, H.A., Azizzadeh, M. and Heidarpour, M. (2015). Relationships between trace elements, oxidative stress and subclinical ketosis during transition period in dairy cows. International Journal of Veterinary Science and Technology, 7(2): 46-56.
Keck, R.G. (1996). The use of t-butyl hydroperoxide as a probe for methionine oxidation in proteins. Analytical Biochemistry, 236(1): 56-62.
Kelly, F.J. and Mudway, I.S. (2003). Protein oxidation at the air-lung interface. Amino Acids, 25(3-4): 375-96.
Li, Y., Ding H.Y., Wang, X.C., Feng, X.B., Li, X.B., Wang, Z., et al. (2016). An association between the level of oxidative stress and the concentrations of NEFA and BHBA in the plasma of ketotic dairy cows. Journal of Animal Physiology and Animal Nutrition, 100(5): 844-851.
Lykkesfeldt, J. and Svendsen, O. (2007). Oxidants and antioxidants in disease: Oxidative stress in farm animals. The Veterinary Journal, 173(3): 502-511.
Macrae, A.I., Whitaker, D.A., Burrough, E., Dowell, A. and Kelly, J.M. (2006). Use of metabolic profiles for the assessment of dietary adequacy in UK dairy herds. Veteran Records, 159(20): 655-661.
Mandebvu, P., Castillo, J. B., Steckley, D.J. and Evans, E. (2003). Total antioxidant capacity: a tool for evaluating the nutritional status of dairy heifers and cows. Canadian Journal of Animal Science, 83(3): 605-608.
Marietta, C., Gulam, H. and Brooks, P.J. (2002). A single 8, 50-cyclo-20-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo. DNA Repair (Amst), 1(11): 967-975.
Mihara, M. and Uchiyama, M. (1978): Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical Biochemistry 86(1): 271-278.
Mohamed, H.E. (2008). Antioxidant status and the degree of oxidative stress in demedary (Camelus dromedaries) with or without endometritis. Veterinary Research, 2(1): 1-2.
Niehaus Jr, W.G. and Samuelsson, B. (1968). Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. European Journal of Biochemistry, 6(1): 126-30.
Omidi, A., Fathi, M.H. and Parker, M.O. (2017). Alterations of antioxidant status markers in dairy cows during lactation and in the dry period. Journal of Dairy Research, 84(1): 49-53.
Poulsen, H.E. (2005). Oxidative DNA modifications. Experimental and Toxicologic Pathology, 57(1): 161-169.
Sahoo, S.S., Parta, R.C., Behera, P.C. and Swarup, D. (2009). Oxidative stress indices in the erythrocytes from lactating cows after treatment for subclinical ketosis with antioxidant incorporated in the therapeutic regime. Veterinary Research Communications, 33(3): 281-290.
Shen, X.P., Zou, S.B., Wu, H.J. and Zhang, Y. (2009). The relationship between serum level of leptin and oxidative stress in patients with hyperglycemia crisis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, 21(6): 353-356.
Walsh, R.B., Walton J.S., Kelton D.F., LeBlanc S.J., Leslie K.E., et al. (2007). The effect of subclinical ketosis in early lactation on reproductive performance of postpartum dairy cows. Journal of Dairy Science, 90(6): 2788-2796.
Yaralioglu-Gurgoze, S., Cetin, H., Cen, O., Yilmaz, S. and Atli, M.O. (2005). Changes in malondialdehyde concentrations and glutathione peroxidase activity in purebred Arabian mares with endometritis. Veterinary Journal, 170(1): 135-137.
Youssef, M.A., El-Khodery, S.A., El-deeb, W.M. Abou and El-Amaiem, W.E.A. (2010). Ketosis in buffalo (Bubalus bubalis): clinical findings and the associated oxidative stress level. Tropical Animal Health and Production, 42(8): 1771-1777.
Zdunczyk, Z., Flis, M., Zielinski, H., Wróblewska, M., Antoszkiewicz, Z. and Juskiewicz, J. (2006). In vitro antioxidant activities of barley, husked oat, naked oat, triticale, and buckwheat wastes and their influence on the growth and biomarkers of antioxidant status in rats. Journal of Agricultural and Food Chemistry, 54(12): 4168-4175.
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Adly, A.A. (2010). Oxidative stress and disease: An updated review. Research Journal of Immunology, 3(2): 129-145.
Albera, E. and Kankofer, M. (2010). The comparison of antioxidative/oxidative profile in colostrum, milk and blood of early post-partum cows during their first and second lactation. Reproduction in Domestic Animals, 45(6): 417-25.
Al-Qudah, K. (2011). Oxidant and antioxidant profile of hyperketonemic ewes affected by pregnancy toxemia. Veterinary Clinical Pathology, 40(l): 60-65.
Andersson, L. (1988). Subclinical ketosis in dairy cows. Veterinary Clinics of North America: Food Animal Practice, 4(2): 233-251.
Baithalu, R.K., Singh, S.K., Kumaresan, A., Mohanty, A.K., Mohanty, T.K., Kumar, S., et al. (2017). Transcriptional abundance of antioxidant enzymes in endometrium and their circulating levels in Zebu cows with and without uterine infection. Animal Reproduction Science, 177: 79-87.
Benzie, I.F. and Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry, 239(1): 70-76.
Bernabucci, U., Ronchi, B., Lacetera, N. and Nardone, A. (2017). Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science, 88(6): 2017-2026.
Birben, E., Sahiner, U.M., Sackesen, C., Erzurum, S. and Kalayci, O. (2012). Oxidative Stress and Antioxidant Defense. World Allergy Organization Journal, 5(1): 9-19.
Caldecott, K.W. (2003). Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31(1): 247-251.
Castillo, C., Hernandez, J., Valverde, I., Pereira, V., Sotillo, J., Alonso, M.L., et al. (2006). Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Research in Veterinary Science, 80(2): 133-139.
Celi, P. (2010). The role of oxidative stress in small ruminant health and production. Revista Brasileira de Zootecnia, 39: 348-363.
Celi, P. and Gabai, G. (2015). Oxidant/antioxidant balance in animal nutrition and health: the role of protein oxidation. Frontiers in Veterinary Science, 2(48): 1-13.
Di Trana, A., Celi, P., Claps, S., Fedele, V. and Rubino, R. (2006). The effect of hot season and nutrition on the oxidative status and metabolic profile in dairy goats during mid-lactation. Animal Science, 82(5): 717-722.
EL-Bahr, S.M. and EL-Deeb, W.M. (2017). Oxidative stress and cardiac biomarkers in lambs affected with enzootic ataxia: the diagnostic and prognostic significance. Veterinarski Arhiv, 87(3): 259-271.
Hanafi, E.M., Ahmed, W.M., Abd El Moez, S.I., El Khadrawy, H.H. and Abd El Hameed, A.R. (2008). Effect of clinical endometritis on ovarian activity and oxidative stress status in Egyptian buffalo-cows. Journal of Agricultural, Food and Environmental Sciences, 4(5): 530-536.
Heidarpour, M., Mohrı, M., Fallah-Rad, A.H., Shahreza, F.D. and Mohammadi, M. (2012). Oxidative stress and trace elements before and after treatment in dairy cows with clinical and subclinical endometritis. Revue de Médecine Vétérinaire, 163(12): 628-633.
Herdt, T.H. (2000). Ruminant adaptation to negative energy balance. Veterinary Clinics of North America: Food Animal Practice, 16(2): 215-230.
Jain, S.K., McVie, R. and Bocchini, J.A. (2006). Hyperketonemia (ketosis), oxidative stress and type 1 diabetes. Pathophysiology, 13(3): 163-70.
Karimi, N., Mohri, M., Seifi, H.A., Azizzadeh, M. and Heidarpour, M. (2015). Relationships between trace elements, oxidative stress and subclinical ketosis during transition period in dairy cows. International Journal of Veterinary Science and Technology, 7(2): 46-56.
Keck, R.G. (1996). The use of t-butyl hydroperoxide as a probe for methionine oxidation in proteins. Analytical Biochemistry, 236(1): 56-62.
Kelly, F.J. and Mudway, I.S. (2003). Protein oxidation at the air-lung interface. Amino Acids, 25(3-4): 375-96.
Li, Y., Ding H.Y., Wang, X.C., Feng, X.B., Li, X.B., Wang, Z., et al. (2016). An association between the level of oxidative stress and the concentrations of NEFA and BHBA in the plasma of ketotic dairy cows. Journal of Animal Physiology and Animal Nutrition, 100(5): 844-851.
Lykkesfeldt, J. and Svendsen, O. (2007). Oxidants and antioxidants in disease: Oxidative stress in farm animals. The Veterinary Journal, 173(3): 502-511.
Macrae, A.I., Whitaker, D.A., Burrough, E., Dowell, A. and Kelly, J.M. (2006). Use of metabolic profiles for the assessment of dietary adequacy in UK dairy herds. Veteran Records, 159(20): 655-661.
Mandebvu, P., Castillo, J. B., Steckley, D.J. and Evans, E. (2003). Total antioxidant capacity: a tool for evaluating the nutritional status of dairy heifers and cows. Canadian Journal of Animal Science, 83(3): 605-608.
Marietta, C., Gulam, H. and Brooks, P.J. (2002). A single 8, 50-cyclo-20-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo. DNA Repair (Amst), 1(11): 967-975.
Mihara, M. and Uchiyama, M. (1978): Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analytical Biochemistry 86(1): 271-278.
Mohamed, H.E. (2008). Antioxidant status and the degree of oxidative stress in demedary (Camelus dromedaries) with or without endometritis. Veterinary Research, 2(1): 1-2.
Niehaus Jr, W.G. and Samuelsson, B. (1968). Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. European Journal of Biochemistry, 6(1): 126-30.
Omidi, A., Fathi, M.H. and Parker, M.O. (2017). Alterations of antioxidant status markers in dairy cows during lactation and in the dry period. Journal of Dairy Research, 84(1): 49-53.
Poulsen, H.E. (2005). Oxidative DNA modifications. Experimental and Toxicologic Pathology, 57(1): 161-169.
Sahoo, S.S., Parta, R.C., Behera, P.C. and Swarup, D. (2009). Oxidative stress indices in the erythrocytes from lactating cows after treatment for subclinical ketosis with antioxidant incorporated in the therapeutic regime. Veterinary Research Communications, 33(3): 281-290.
Shen, X.P., Zou, S.B., Wu, H.J. and Zhang, Y. (2009). The relationship between serum level of leptin and oxidative stress in patients with hyperglycemia crisis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, 21(6): 353-356.
Walsh, R.B., Walton J.S., Kelton D.F., LeBlanc S.J., Leslie K.E., et al. (2007). The effect of subclinical ketosis in early lactation on reproductive performance of postpartum dairy cows. Journal of Dairy Science, 90(6): 2788-2796.
Yaralioglu-Gurgoze, S., Cetin, H., Cen, O., Yilmaz, S. and Atli, M.O. (2005). Changes in malondialdehyde concentrations and glutathione peroxidase activity in purebred Arabian mares with endometritis. Veterinary Journal, 170(1): 135-137.
Youssef, M.A., El-Khodery, S.A., El-deeb, W.M. Abou and El-Amaiem, W.E.A. (2010). Ketosis in buffalo (Bubalus bubalis): clinical findings and the associated oxidative stress level. Tropical Animal Health and Production, 42(8): 1771-1777.
Zdunczyk, Z., Flis, M., Zielinski, H., Wróblewska, M., Antoszkiewicz, Z. and Juskiewicz, J. (2006). In vitro antioxidant activities of barley, husked oat, naked oat, triticale, and buckwheat wastes and their influence on the growth and biomarkers of antioxidant status in rats. Journal of Agricultural and Food Chemistry, 54(12): 4168-4175.
