Introduction: The aim of this research was to study the effect of eight weeks of aerobic training with ginger supplementation on plasma visfatin and lipid profile in obese men. Methods: Forty volunteer middle-aged obese men were divided randomly into four equal groups (n=10) including; placebo, ginger supplement, aerobic training and aerobic training with ginger supplement. Aerobic training consisted of eight weeks, three sessions per week and intensity of 55-65 percentage of maximum heart rate. Ginger supplementation consisted of 3 gr ginger consumption as capsule, three times before each meal for eight weeks. Changes of plasma levels of visfatin and lipid profile were assayed before and after eight weeks. Data were analyzed using one-way ANOVA test and Tucky’s post-hoc comparison (p<0.05). Results: There was significant difference between groups in plasma levels of visfatin (p=0.03), VLDL (p=0.01) and TG (p=0.03). The observed difference was related to placebo and aerobic training with ginger supplement groups. Conclusion: It seems that eight weeks of aerobic training with ginger supplementation may improve some cardiovascular risk factors in middle-agesd obese men. Manuscript profile