Abstract. In this study, the Box-Behnken design (BBD) was used in the response surface method (RSM) to investigate the modeling and optimization parameters in the synthesis of a 1,5-Benzodiazepine. This method was used to optimize the influencing factors in the synthesis process of this material, including the amount of nanocatalyst, temperature, and reaction time. The obtained mathematical model was analyzed by variance analysis. To determine the optimal conditions, graphs of graphic counters and response levels were used. The results showed that the amount of nanocatalyst has the greatest effect on the synthesis reaction of 1.5 Benzodiazepines. The maximum efficiency for the synthesis of the product was determined at a temperature of 283 K, the amount of CuFe2O4/Clinoptilolite = 6 grams per liter and time = 60 minutes. Manuscript profile

In this study, nanocatalysts of GO/ZnO/Mn/Co for the reaction of xanthene and amido alkyl naphthol were studied. First, the optimal conditions for these two reactions were obtained and then the effect of zinc oxide nanoparticles on this reaction was studied. To do this, study the graphene oxide catalyst with the presence and absence of ZnO and then different conditions such as the amount of catalysis, the reaction temperature, the reaction time, and finally the appropriate solvent to perform both reactions optimally. Finally, the conditions of these reactions for the synthesized of derivatives under thermal and ultrasonic conditions are studied and the results show that this catalyst has a good ability to perform these two reactions because with a small amount of catalyst excellent yield is obtained with high efficiency and also recyclability several times for xanthene and amido alkyl naphthol derivatives. The products were characterized by FT-IR, NMR spectra, and melting point. Manuscript profile

In this study, the Box-Behnken design (BBD) was used in the response surface method (RSM) to investigate the modeling and optimization parameters in the synthesis of a 1,5-Benzodiazepine. This method was used to optimize the influencing factors in the synthesis process of this material, including the amount of nanocatalyst, temperature, and reaction time. The obtained mathematical model was analyzed by variance analysis. To determine the optimal conditions, graphs of graphic counters and response levels were used. The results showed that the amount of nanocatalyst has the greatest effect on the synthesis reaction of 1.5 Benzodiazepines. The maximum efficiency for the synthesis of the product was determined at a temperature of 283 K, the amount of CuFe2O4/Clinoptilolite = 6 g/lr and time = 60 minutes. Manuscript profile