Given the need to increase the efficiency of heat transfer in thermal systems, especially systems using nanofluids in microscale and nanoscale heat transfer equipment ideas to improve their performance is very good.In present study, the flow and heat transfer of Water-Cu nanofluid in micro-tube with slip regime with constant wall heat flux numerically simulated with low Reynolds numbers. Slip velocity and temperature jump boundary conditions are also considered along the microtube walls, for first time. The results are presented as the profiles of temperature and velocity. Nusselt number and pressure drop coefficient calculated in interance and full developed region. The effect of slip and using nano particle considerd.It is observed that Nusselt number increases with slip velocity coefficient and pressure drop coefficient decreases; att intrance region the Raynolds of flow has effect on Nusselt and pressure drop coefficient,too.Likewise observed nano particle adding to water has low effect to increases Nusselt number and pressure drop coefficientt. Manuscript profile