Introduction: The immune system is composed of several functional components that respond to a variety of stimuli such as training. The aim of training is to preserve body homeostasis at a reasonable level. The effects of carbohydrate ingestion on training-induced alterations in the immune functions have been comprehensively investigated in past. The aim of this research was to review the effect of continuous aerobic training with low carbohydrate diet on immunoglobulins A, G and M in overweight adult men. Methods: 30 men with age range of 36-50 years and BMI between 25- 30 Kg/m2 were selected and divided into three groups of 10 subjects randomly (control, training, training with low carbohydrate diet). Groups training and training with low carbohydrate diet performed continuous aerobic trainings 3 sessions per week for 8 weeks and low carbohydrate diet was implemented for 8 weeks with 43- 47 % of total received energy of carbohydrates and 36- 40 % of lipids in the diet. The blood samples were taken before beginning the main study program and after 8 weeks of aerobic trainings. The paired sample t- test, one way ANOVA and Tukey’s post hoc tests were used to compare the pre-test and post-test data between the groups (p≤0.05). Results: the results showed that eight weeks of training and eight weeks of training with low carbohydrate diet significantly reduced IgA, IgG and IgM (P<0.05). Conclusion: It appears that performing continuous aerobic training with low carbohydrate diet causes a significant drop in plasma levels of immunoglobulins A, G and M and suppress the immune system. Manuscript profile