مروری بر تکامل ساختاری و عملکرد مغز خزندگان همراه با اولین گزارش از وقوع گلیوبلاستوما مولتی فورمه با جزء عصبی اولیه در روباه مار
محورهای موضوعی : پاتوبیولوژی مقایسه ایپیمان محمدزاده 1 , سجاد محمدی 2
1 - گروه پاتوبیولوژی دانشکده دامپزشکی، دانشگاه ازاد اسلامی واحد سنندج، ایران
2 - دانشجوی دوره دکترای عمومی دامپزشکی، دانشگاه ازاد اسلامی واحد سنندج ایران
کلید واژه: گلیوبلاستوما مولتی فورمه همراه, مغز خزندگان, روباه مار, ایمونوهیستوشیمی, پاتولوژی,
چکیده مقاله :
گلیوبلاستوما مولتی فرمه شایع ترین تومور بدخیم سیستم عصبی مرکزی است و گلیوبلاستوما همراه با اجزای عصبی اولیه یک نوع بسیار نادر و تهاجمی است که در 0.5٪ از گلیوبلاستوماها شناسایی شده است و از لحاظ بافت شناسی یک الگوی منحصر به فرد از آن به حساب می اید. متاستاز خارج جمجمه ای این تومور یک وضعیت نادر و چالش برانگیز است. در این مطالعه، ویژگیهای مورفولوژیکی و ایمونوهیستوشیمی یک مورد گلیوبلاستوما با مولفه عصبی اولیه تشخیص داده شده در یک حلقه روباه مار نر 7 ساله را همراه با بررسی ادبیات جامع در ارتباط با وقوع تومورهای بدخیم در خزندگان را بررسی می کنیم. علائم بصورت وجود یک توده برجسته برروی سرودرگیری سیستم عصبی مرکزی بود اقدامات تشخیصی شامل بررسیهای هماتولوژیکی و سرولوژی و RT-PCR و Nested-PCR و MRI و CT-SCAN انجام شد و پس از مرگ کالبدگشایی و مطالعه پاتولوژی و ایمونوهیستوشیمی انجام گردید. بر اساس داده های بالینی ابتلا به گلیوبلاستوما مولتی فورمه همراه با اجزای عصبی اولیه تایید شد.در مورد حاضر وقوع و شدت متاستاز خارج جمجمه ای محوری گسترده از GBM-PNC برجسته بود. از آنجایی که هیچ پروتکل درمانی مناسب هنوز توسعه پیدا نکرده است و اخیراً نشان داده شده است که GBM-PNC دارای رفتار بالینی PNC بیشتر با افزایش خطر گسترش به CSF همراه است، بنابراین درک ویژگیهای بالینی،تشخیصی و هیستوپاتولوژی این تومور و تعیین شباهتها و اختلافات رفتاری این تومور در گونه های مختلف می تواند گامی بلند به سمت شناخت ماهیت و نحوه مقابله با آن باشد.
Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. GBM with primitive neuronal component (GBM-PNC) is an aggressive variant identified in 0.5% of GBMs and recognized as a distinct histological pattern of glioblastoma Extracranial metastasis from GBM-PNC is a rare and challenging situation. In this study we report the morphological and immunohistochemical features of a case of glioblastoma with primitive neuronal component diagnosed in a 7-year-old male eastern fox snake (Pantherophis gloydi), along with a comprehensive literature review related to the occurrence of malignant tumors in reptiles. Symptoms included a prominent mass on the head, and involvement of the central nervous system. Diagnostic measures including hematological and serological examinations, RT-PCR, Nested-PCR, MRI and CT-SCAN were performed. And after death, Necropsy and pathology and immunohistochemistry study were performed. Based on clinical data, glioblastoma multiforme with primary neurological components was confirmed. The present case highlights the occurrence and severity of extensive axial skeletal metastases from GBM-PNC. Since there is no treatment protocol established for GBM-PNC and GBM-PNC has recently been shown to have more PNC clinical behavior with increased risk of CSF spread, so understanding the clinical, diagnostic and histopathological features of this tumor and determining similarities and Behavioral differences of this tumor in different species can be a big step towards understanding its nature and how to deal with it.
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