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مقاله
1 - Synthesis and Molecular Docking studies of Some Tetrahydroimidazo[1,2-a] pyridine Derivatives as Potent α-Glucosidase InhibitorsJournal of Applied Chemical Research , شماره 1 , سال 15 , زمستان 2021KAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields an چکیده کاملKAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times. Docking study of some compounds in the active site of α-glucosidase demonstrated that these compounds interacted with important active site residues with low binding energy in comparison to standard inhibitor acarbose. پرونده مقاله -
مقاله
2 - BF3-SiO2 Nanoparticles: An Efficient Catalyst for the Multi-Component Synthesis of 3-(α-aroylamido) 4-hydroxycoumarin Derivatives in WaterJournal of Applied Chemical Research , شماره 4 , سال 13 , تابستان 2019A green and efficient one-pot three component reaction of 4-hydroxycoumarin or 1,3-dimethylbarbutyric acid, aryl glyoxals and amides (thioacetamide) has been developed in the presence of BF3- SiO2 nanoparticles in water. This method has several advantages such as high t چکیده کاملA green and efficient one-pot three component reaction of 4-hydroxycoumarin or 1,3-dimethylbarbutyric acid, aryl glyoxals and amides (thioacetamide) has been developed in the presence of BF3- SiO2 nanoparticles in water. This method has several advantages such as high to excellent product yields in short reaction time, atom economy, environment friendly, reusable catalyst and no need for chromatographic separations. پرونده مقاله -
مقاله
3 - Synthesis and Physicochemical Characterization of New Amidic Derivative of Sodium AlginateShokouh Khodayar Mohammad Reza Shushizadeh Elham Tahanpesar Behzad Sharif Makhmalzadeh Haleh Sanaeishoarjournal of chemical reactivity and synthesis , شماره 5 , سال 13 , پاییز 2023In this study, our objective was to synthesis a new derivative of alginate, a natural biocompatible, biodegradable and non-toxic biopolymer to improve the gelling mechanism. For this purpose, ethylenediamine (EDA) was coupled to sodium alginate (NaA) in an aqueous-phase چکیده کاملIn this study, our objective was to synthesis a new derivative of alginate, a natural biocompatible, biodegradable and non-toxic biopolymer to improve the gelling mechanism. For this purpose, ethylenediamine (EDA) was coupled to sodium alginate (NaA) in an aqueous-phase reaction using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl) and N-hydroxy succinimide (NHS) as coupling reagents to synthesis ethylenediamine-grafted amphiphilic sodium alginate-amide derivative (NaA-g-EDA). Synthesized derivative showed no environmental sensitivity but the swelling percentage of hydrogels shows that hydrogels obtained from NaA-g-EDA had higher water absorption compared to non-functionalized sodium alginate. It seems that hydrogels can uptake water more than 100% of their weight but in a slow manner. This character is a perfect property for wound dressing. Biodegradable synthesized hydrogel can be decomposed into non-toxic by-products. The purity and grafting of copolymers were characterized using fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR), X-ray diffraction (XRD), and elemental analysis (CHNX). These analytical methods confirmed the structure of NaA-g-EDA. پرونده مقاله