Introduction: Myocardial infarction is cell death in part of the myocardial
during an ischemia. Cell death process in response to activity and appropriate intensity is not clear yet. Therefore, the aim of this study was to evaluate the effect of eight weeks of high intensity interval training on endothelial constitutive nitric oxide synthase, hypoxia-induced factor-1 and vascular endothelial growth factor in rats with myocardial infarction. Methods: 12 male Wistar rats weighing 250 to 300 grams were assigned into two groups: the experimental group (60 minutes running on a treadmill on an interval basis, each interval four minutes with intensity of 85-90 and two minutes of active recovery with 50- 60 % VO2max, Four days a week for eight weeks) and the control group (without training intervention). Genes expression were investigated by the PCR technique. Data were analyzed using SPSS (version 18) with Independent sample t-test (p≤0.05). Results: The results showed that endothelial constitutive nitric oxide synthase in high intensity interval training group (4.755) was significantly higher than the control group (3.615) (p= 0.012), hypoxia-induced factor in high intensity interval training group (9.015) was significantly higher than control group (1.49) (p= 0.001) and vascular endothelial growth factor in high intensity interval training group (6.855) was significantly higher than control group (1.425) (p= 0.001). Conclusion: Generally, eight weeks of high intensity interval training with increasing endothelial constitutive nitric oxide synthase and hypoxia- induced factor- 1 increased vascular endothelial growth factor and eventually increased angiogenesis and improved cardiac function in male rats after myocardial infarction. پرونده مقاله

Introduction: Levosimendan is a calcium sensitive inotrope and ATP-sensitive potassium channel opener that is effective in the prevention and treatment of low cardiac output syndrome (LCOS) after cardiac surgery. The purpose of this study was to investigate the need for inotrope during ICU admission, the incidence of myocardial infarction within 3 days after surgery, the need for insertion of intra-aortic balloon pump within 3 days after surgery, and examining the time of extubation of the endotracheal tube and the time of discharge from the ICU. Methods: In this randomized clinical trial, 60 patients with mean age of 65 years with left ventricular ejection fraction (% 30 ≥) (LVEF), who were candidates of off pump coronary artery bypass graft surgery were examined.
Patients were screened for 20 days before surgery and those with renal insufficiency or liver failure as well as those who simultaneously needed to use inotropic or vasopressor drugs or were candidates for cardiac surgery using a cardiopulmonary pump were excluded. Patients were randomly divided into experimental and control groups. After insertion of the arterial catheter and simultaneously with the skin incision in the experimental group, intravenous prophylactic levosimendan (0.1μg / kg / min) was used from the start of surgery to 24 hours after surgery. The control group did not receive any inotrope. For statistical analysis of data U Mann-Whitney test and Chi-square test were used (P< 0.05). Results: The use of levosimendan had no significant effect on the time of extubation of the endotracheal tube in the ICU (p = 0.336); Also, levosimendan had no significant effect on the time of discharge of patients from ICU (p = 0.292). However, the use of levosimendan had a significant effect on the need for insertion of intra-aortic balloon pump (IABP) (p = 0.038) as well as the incidence of myocardial infarction (p <0.001), and reduced the incidence of myocardial infarction (p=0.001) and the percentage of need for insertion of intra-aortic balloon pump (IABP).) (p = 0.038). Conclusion: According to findings of the present study, it is recommended to use levosimendan to reduce the incidence of myocardial infarction and reduce the need for insertion of intra-aortic balloon pump in patients with left ventricular dysfunction in off pump coronary artery bypass graft surgery. پرونده مقاله