Coumarins and their derivatives are bioactive compounds recognized for their diverse range of health-promoting properties. This systematic review aims to identify and summarize the natural sources of coumarins and their derivatives. Electronic databases, including PubMed, Scopus, and Web of Science, were thoroughly searched with precise keywords and inclusion/exclusion criteria. Studies published in English from 2000 to 2023 were considered for inclusion. Natural sources of coumarins and their derivatives were identified, including plants, fungi, and bacteria. Some common plant families known to contain coumarins and their derivatives were Asteraceae, Rutaceae, and Fabaceae. The health-promoting properties of coumarins and their derivatives were found to be extensive. Many studies have reported their antioxidant, anti-inflammatory, anticancer, antibacterial, and antifungal activities. The compounds have shown potential in protecting against cardiovascular diseases, neurodegenerative disorders, diabetes, and obesity. Understanding the structure-activity relationships of these compounds is crucial for further research and development in this area. پرونده مقاله