Background & Aim: Medicinal plants, Since time immemorial, have been used in virtually all cultures as a source of medicine and ethnobotany has prevent to be a valuable method to find new herbal medicine and plant derived drugs.Material & Methods: This study determined medicinally important plants that are most frequently by the local inhabitants of Sistan to treat human diseases. In current consideration, identification, classification and introduction of these plants in Sistan have been conducted using physiognomic methods, public knowledge, corresponding with document studies. Medicinal plants were collected from various places of Sistan and recognized by using flora. For each plant species, botanical name, vernacular name, part (s) used, popular medicinal use, forms of preparation and application of the herbal remedies are provided.Results & Discussion: These plants are used in traditional medicine as diuretic, stomach improver, wound healing agent , antipyretic , anti wound healing agent , expectorant, etc.Conclusion: Some important medicinal species which were identified including Citrullus colocynthis, Aloe vera, Peganum harmala, Ziziphus jujube, Eucalyptus camaldulensis, etc. پرونده مقاله