In the nanochannel flow behavior with respect to expand their applications in modern systems is of utmost importance. According to the results obtained in this study, the condition of nonslip on the wall of the nanochannel is not acceptable because in the nano dimensions, slip depends on different parameters including surface roughness. In this study, keeping the side area roughness, deformation effects on fluid flow behavior is investigated. Modeling software open source LAMMPS with equilibrium molecular dynamics simulations have been carried out. Unlike previous studies, existence fluid in laboratory conditions as water-copper nanofluids used. The results showed that rectangular was the most effective and triangular was least effective roughness on flow behavior, resulting in a rough triangular nanochannel slip occurs with more intensity.Existence roughness on the surface increases the number of oscillations in the fluid layer but amplitude near the wall is smooth to rough increased. Nanoparticles also increase the impact on the flow properties پرونده مقاله