Introduction: Depression may affect up to 50% of the multiple sclerosis (MS) population and can significantly impact other symptoms such as fatigue and pain, as well as negatively affecting cognition and quality of life. Exercise may be a potential treatment to prevent or reduce depressive symptoms in individuals with MS, but existing studies do not allow solid conclusions. The present study was conducted to determine the effect of 8 weeks resistance exercise on depression, adrenocotrotropic hormone (ACTH) and cortisol concentration in female patients with MS. Material & Methods: 27 women with MS (mean of age of 32.3 ± 6.9 years) with Expanded Disability Status Scale (EDSS) scores lower than 4.5 were randomly assigned to training or control group. The training group performed progressive resistance training program, 3 days a week for 8 weeks, whereas control group continued their usual routine activities. Depression was measured by Beck Depression Inventory (BDI) and plasma level of ACTH and cortisol were measured by ELISA kits before and after training. Data were analyzed by ANCOVA. Results: Results of ANCOVA test indicated that BDI score improves after 8 weeks resistance training (F=12.3, P=0.001). ACTH concentrations were increased (F=26.6, P=0.001) and cortisol levels were decreased (F=26.0, P=0.001) significantly after the intervention. Conclusions: These results suggest that resistance training improves depression symptoms and its related hormones in female patients with MS. پرونده مقاله

Introduction: Fatigue occurs in the majority of patients with multiple sclerosis (MS) and MS – related fatigue is strongly linked to impaired physical activity. Exercise may have beneficial effects on both fatigue and physical performance in MS patients however it is not well known. The aim of this study was to examine the effects of 8 weeks resistance training (RT) on fatigue levels, hormonal related fatigue and physical fitness in female patients with MS. Material & Methods: Twenty seven female with MS disease in a range of 18-48 year of old and EDSS lower than 4.5 participated in this study as the subject. Subjects were divided into control group (n=13) or training group (n=14) randomly.The training group performed progressive RT program, 3 days a week for 8 weeks. Results: The results showed that fatigue levels decreased and right leg balance (RLB), left leg balance (LLB) and muscular endurance improved after 8 weeks RT compare to the control group (P<0.05). For serum levels of dehydroepiandrestrone sulfate (DHEA-S) no significant differences were observed after the intervention. Conclusions: The results suggest RT with specific intensity and duration utilized in this study improves decrease fatigue levels and improved physical fitness in female patients with MS. پرونده مقاله