The Effect of Moderate Intensity Interval Training on Mitochondrial Biogenesis Markers of Rats Fed a High Fat Diet

Subject Areas : Physical Activity and Health

Ahmad Khajvand Abedini ¹ (Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran)
Ahmad Abdi ² (Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.)
Alireza Barari ³ (Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran)
ghasem Torabi Palat Kaleh ⁴ (Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran)
mostafa Kazemi ⁵ (Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran)
Masoomeh Alsadat Mirshafaei ⁶ (Master of sport physiology, Department of physical education & sport sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran)

Received: 2022-02-03 Accepted : 2022-06-11 Published : 2022-06-22

Keywords:

Abstract :

PGC-1α has been reported to play an essential role in skeletal muscle mitochondrial biogenesis in collaboration with Nrf2. The aim of the present study was to investigate the effect of moderate intensity interval training on mitochondrial biogenesis markers in mice fed a high fat diet. In this experimental study, 24 male rats were randomly divided into three groups (n=9): Normal Diet (ND), High-Fat Diet (HFD) and High-Fat Diet +Training (HFDT). The training group performed moderate intensity interval training (MIIT) on the treadmill for 8 weeks and 5 sessions per week. The MIIT program includes 13 repetitions of 4-minute activity with an intensity of 16-25 meters per minute, with 2-minute rest periods. Data were analyzed using ANOVA at p<0.05. There was a significant decrease in the relative expression of PGC-1α (p=0.0001) and Nrf2 (p=0.0001) in HFD groups compared to CN. Also, the relative expression of PGC-1α (p=0.0001) and Nrf2 (p=0.0001) increased significantly in HFDT groups compared to HFD. It seems that MIIT by increasing the expression of PGC-1α and Nrf2 is a suitable method to improve the performance of mitochondrial biogenesis in HFD-fed rats.

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