The ability of Plasmonic nanoparticles (PNPs) to efficiently convert absorbed light energy into localized heat has made them a popular choice for photothermal medical applications. However, during the photothermal process, the diffusion of localized heat can lead to temperature management challenges. To address this issue, researchers have developed a new generation of PNPs incorporating optical phase transition materials, allowing for tunable photothermal responses without altering the geometry. This tunability is achieved through rapid changes in optical and thermal properties during phase transitions. In this study, we conducted a numerical analysis on the photothermal response of a VO2@Au smart nanoshell in both tumor and healthy liver tissue under irradiation with a nanosecond (5 ns) pulsed laser. To obtain the temperature profile, we solved a coupling problem between electromagnetism and thermodynamics. Manuscript profile