Background & Aim: Investigating the effects of medicinal plants on the basal physiology of the body is one of the main topics in the application of medicinal plants. Hyssop (Hyssopus officinalis) or Zofa is one of most important medicinal plants in Iran with numerous therapeutic properties such as antibacterial, antifungal, anti-inflammatory, and analgesic effects. However, there is limited information on its effects on the basal physiology of the body. The aim of this study was to investigate the effects of hydroalcoholic extract of hyssop on liver and kidney activities in rats under normal physiological conditions.Experimental: For this purpose, 32 male rats of the Wistar breed were used. The rats were allocated to one control group and three experimental groups. The experimental groups received the hydroalcoholic extract of Zufa at 150, 100 and 50 mg/kg concentration levels for 21 days. After the trial, blood samples were collected to measure liver and kidney health indices.Results: The results showed that hyssop extract did not significantly affect cholesterol and ALT levels (P>0.05); while, significantly reduction in AST levels was observed. Consumption of hyssop extract at the concentration of 150 mg/kg b.w significantly increased GGT level (P<0.05); however, a significant decrease (P<0.05) was observed in creatinine and BUN parameters at the concentration level of 100 mg/kg. Consumption of hyssop extract did not affect HDL levels, whereas, at the concentration level of 150 mg/kg, LDL levels were significantly decreased (P<0.05). Moreover, a decreasing trend in glucose and triglyceride levels was observed with the consumption of hyssop extractRecommended applications/industries: Generally, Zufa extract at 100 mg/kg concentration level can effectively lower blood sugar without any negative effects on the liver and kidney health. Manuscript profile

Background & Aim:Evaluation of the effects of medicinal herbs on the metabolism and physiology of the body is considered as one of the fundamental researches about the use of herbs in medicine. The present study aimed to investigate the effects of hydroalcoholic extract of Dandelion (Taraxacum officinale) leaf on liver and kidney function of the rats in normal physiological conditions. Experimental: The Wistar adult male rats (n=32) were divided into 4 groups of control, 50, 100 and 200 based on the concentration of the hydroalcoholic extract fed to rats (mg/kg body weight). Dandelion leaf extract was administered by gavage for 20 days. Blood samples were taken from the heart to assess the health parameters of the liver (cholesterol, triglyceride and liver enzymes) and kidney (urea, urea nitrogen, and creatinine). Results: The concentrations of cholesterol and triglyceride were significantly increased in the extract-treated groups compared to the control. Levels of Gamma-glutamyl transferase (GGT) and aspartate aminotransferase (AST) were not significantly different between the treated groups and the control. However, alanine aminotransferase (ALT) levels were significantly increased in the extract-treated groups. Kidney health assessment showed that consumption of Dandelion leaf extract reduced the concentrations of urea, urea nitrogen, and creatinine. In addition, the concentration of these indicators at lower doses of the extract (50, was more significant. Recommended applications/industries: The present study showed that under normal physiological conditions; consumption of hydroalcoholic extract of Dandelion leaf at low doses had no negative effects on liver and kidney functions. Manuscript profile

بنزوپیرن به عنوان یک ترکیب کارسینوژن و اکسیداتیو شناخته شده است. سیاتوسه حاوی فلاوونوئیدها با فعالیت آنتی اکسیدانی قوی است که از سلول ها در برابر استرس اکسیداتیو و مرگ سلولی محافظت می کند. هدف از مطالعه حاضر بررسی اثرات آنتی اکسیدانی سیاتوسه در برابر عوارض حاصل از مواجهه با بنزوپیرن در مقایسه با ویتامین E در موش‌ بود. موش های سوری نر به طور تصادفی به 11 گروه کنترل، دریافت کننده روغن زیتون (حلال بنزوپیرن)، ویتامین E، بنزوپیرن، سیاتوسه در سه دوز، بنزوپیرن همراه دوزهای مختلف سیاتوسه و بنزوپیرن به همراه ویتامین E تقسیم شدند. به منظور مقایسه میانگین داده ها از آزمونهای آماری ANOVA و Tukey استفاده شد. بنزوپیرن باعث کاهش آنتی اکسیدانها و افزایش MDA در خون می شود. این تغییرات به طور قابل توجهی در گروه مواجهه یافته با دوزهای بالای سیاتوسه بهبود یافت، درحالیکه تیمار ویتامین E قادر به کاهش استرس اکسیداتیو ناشی از بنزوپیرن نشد. نتایج نشان داد که عصاره هیدروالکلی سیاتوسه با بهبود پارامترهای آنتی اکسیدانی و کاهش پراکسیداسیون لیپیدی، نقش مهمی در برابر سمیت اکسیداتیو بنزوپیرن ایفا می کند که حتی می تواند در حیوانات آزمایشگاهی بهتر از ویتامین E عمل کند.

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